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Redox Homeostasis in Poultry: Regulatory Roles of NF-κB

Redox biology is a very quickly developing area of modern biological sciences, and roles of redox homeostasis in health and disease have recently received tremendous attention. There are a range of redox pairs in the cells/tissues responsible for redox homeostasis maintenance/regulation. In general,...

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Autores principales: Surai, Peter F., Kochish, Ivan I., Kidd, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912633/
https://www.ncbi.nlm.nih.gov/pubmed/33525511
http://dx.doi.org/10.3390/antiox10020186
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author Surai, Peter F.
Kochish, Ivan I.
Kidd, Michael T.
author_facet Surai, Peter F.
Kochish, Ivan I.
Kidd, Michael T.
author_sort Surai, Peter F.
collection PubMed
description Redox biology is a very quickly developing area of modern biological sciences, and roles of redox homeostasis in health and disease have recently received tremendous attention. There are a range of redox pairs in the cells/tissues responsible for redox homeostasis maintenance/regulation. In general, all redox elements are interconnected and regulated by various means, including antioxidant and vitagene networks. The redox status is responsible for maintenance of cell signaling and cell stress adaptation. Physiological roles of redox homeostasis maintenance in avian species, including poultry, have received limited attention and are poorly characterized. However, for the last 5 years, this topic attracted much attention, and a range of publications covered some related aspects. In fact, transcription factor Nrf2 was shown to be a master regulator of antioxidant defenses via activation of various vitagenes and other protective molecules to maintain redox homeostasis in cells/tissues. It was shown that Nrf2 is closely related to another transcription factor, namely, NF-κB, responsible for control of inflammation; however, its roles in poultry have not yet been characterized. Therefore, the aim of this review is to describe a current view on NF-κB functioning in poultry with a specific emphasis to its nutritional modulation under various stress conditions. In particular, on the one hand, it has been shown that, in many stress conditions in poultry, NF-κB activation can lead to increased synthesis of proinflammatory cytokines leading to systemic inflammation. On the other hand, there are a range of nutrients/supplements that can downregulate NF-κB and decrease the negative consequences of stress-related disturbances in redox homeostasis. In general, vitagene–NF-κB interactions in relation to redox balance homeostasis, immunity, and gut health in poultry production await further research.
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spelling pubmed-79126332021-02-28 Redox Homeostasis in Poultry: Regulatory Roles of NF-κB Surai, Peter F. Kochish, Ivan I. Kidd, Michael T. Antioxidants (Basel) Review Redox biology is a very quickly developing area of modern biological sciences, and roles of redox homeostasis in health and disease have recently received tremendous attention. There are a range of redox pairs in the cells/tissues responsible for redox homeostasis maintenance/regulation. In general, all redox elements are interconnected and regulated by various means, including antioxidant and vitagene networks. The redox status is responsible for maintenance of cell signaling and cell stress adaptation. Physiological roles of redox homeostasis maintenance in avian species, including poultry, have received limited attention and are poorly characterized. However, for the last 5 years, this topic attracted much attention, and a range of publications covered some related aspects. In fact, transcription factor Nrf2 was shown to be a master regulator of antioxidant defenses via activation of various vitagenes and other protective molecules to maintain redox homeostasis in cells/tissues. It was shown that Nrf2 is closely related to another transcription factor, namely, NF-κB, responsible for control of inflammation; however, its roles in poultry have not yet been characterized. Therefore, the aim of this review is to describe a current view on NF-κB functioning in poultry with a specific emphasis to its nutritional modulation under various stress conditions. In particular, on the one hand, it has been shown that, in many stress conditions in poultry, NF-κB activation can lead to increased synthesis of proinflammatory cytokines leading to systemic inflammation. On the other hand, there are a range of nutrients/supplements that can downregulate NF-κB and decrease the negative consequences of stress-related disturbances in redox homeostasis. In general, vitagene–NF-κB interactions in relation to redox balance homeostasis, immunity, and gut health in poultry production await further research. MDPI 2021-01-28 /pmc/articles/PMC7912633/ /pubmed/33525511 http://dx.doi.org/10.3390/antiox10020186 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Surai, Peter F.
Kochish, Ivan I.
Kidd, Michael T.
Redox Homeostasis in Poultry: Regulatory Roles of NF-κB
title Redox Homeostasis in Poultry: Regulatory Roles of NF-κB
title_full Redox Homeostasis in Poultry: Regulatory Roles of NF-κB
title_fullStr Redox Homeostasis in Poultry: Regulatory Roles of NF-κB
title_full_unstemmed Redox Homeostasis in Poultry: Regulatory Roles of NF-κB
title_short Redox Homeostasis in Poultry: Regulatory Roles of NF-κB
title_sort redox homeostasis in poultry: regulatory roles of nf-κb
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912633/
https://www.ncbi.nlm.nih.gov/pubmed/33525511
http://dx.doi.org/10.3390/antiox10020186
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