Cargando…

Role of Kallikrein 7 in Body Weight and Fat Mass Regulation

Increased plasma and adipose tissue protease activity is observed in patients with type 2 diabetes and obesity. It has been proposed that specific proteases contribute to the link between obesity, adipose tissue inflammation and metabolic diseases. We have recently shown that ablation of the serine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kunath, Anne, Weiner, Juliane, Krause, Kerstin, Rehders, Maren, Pejkovska, Anastasija, Gericke, Martin, Biniossek, Martin L., Dommel, Sebastian, Kern, Matthias, Ribas-Latre, Aleix, Schilling, Oliver, Brix, Klaudia, Stumvoll, Michael, Klöting, Nora, Heiker, John T., Blüher, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912635/ https://www.ncbi.nlm.nih.gov/pubmed/33572949 http://dx.doi.org/10.3390/biomedicines9020131

Ejemplares similares

Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo
por: Zieger, Konstanze, et al.
Publicado: (2017)

Vaspin inhibits kallikrein 7 by serpin mechanism
por: Heiker, John T., et al.
Publicado: (2013)

The Fabp4-Cre-Model is Insufficient to Study Hoxc9 Function in Adipose Tissue
por: Dommel, Sebastian, et al.
Publicado: (2020)

The polygenetically inherited metabolic syndrome of male WOKW rats is associated with enhanced autophagy in adipose tissue
por: Kosacka, Joanna, et al.
Publicado: (2013)

Differential expression of immunoregulatory cytokines in adipose tissue and liver in response to high fat and high sugar diets in female mice
por: Weiner, Juliane, et al.
Publicado: (2023)

Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity
por: Gruba, Natalia, et al.
Publicado: (2019)

Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation
por: Weiner, Juliane, et al.
Publicado: (2017)

Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue
por: Dommel, Sebastian, et al.
Publicado: (2021)

Tamoxifen treatment causes early hepatic insulin resistance
por: Klöting, Nora, et al.
Publicado: (2020)

Leptin counteracts hypothermia in hypothyroidism through its pyrexic effects and by stabilizing serum thyroid hormone levels
por: Weiner, Juliane, et al.
Publicado: (2021)

Myoglobin‐mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans
por: Christen, Lisa, et al.
Publicado: (2022)

Di-(2-Ethylhexyl)-Phthalate (DEHP) Causes Impaired Adipocyte Function and Alters Serum Metabolites
por: Klöting, Nora, et al.
Publicado: (2015)

Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice
por: Weiner, Juliane, et al.
Publicado: (2016)

Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)—A CleavEx Based Analysis
por: Falkowski, Katherine, et al.
Publicado: (2020)

COMP-Angiopoietin-1 Recovers Molecular Biomarkers of Neuropathy and Improves Vascularisation in Sciatic Nerve of ob/ob Mice
por: Kosacka, Joanna, et al.
Publicado: (2012)

Does C-C Motif Chemokine Ligand 2 (CCL2) Link Obesity to a Pro-Inflammatory State?
por: Dommel, Sebastian, et al.
Publicado: (2021)

Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue
por: Mardinoglu, Adil, et al.
Publicado: (2015)

A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity
por: Skala, Wolfgang, et al.
Publicado: (2016)

Investigations on Primary Cilia of Nthy-ori 3-1 Cells upon Cysteine Cathepsin Inhibition or Thyrotropin Stimulation
por: Doğru, Alara Gaye, et al.
Publicado: (2023)

Secretome and degradome profiling shows that Kallikrein‐related peptidases 4, 5, 6, and 7 induce TGFβ‐1 signaling in ovarian cancer cells
por: Shahinian, Hasmik, et al.
Publicado: (2013)

A Human REPIN1 Gene Variant: Genetic Risk Factor for the Development of Nonalcoholic Fatty Liver Disease
por: Abshagen, Kerstin, et al.
Publicado: (2020)

Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health
por: Ribas-Latre, Aleix, et al.
Publicado: (2016)

Nutrients and the Circadian Clock: A Partnership Controlling Adipose Tissue Function and Health
por: Ribas-Latre, Aleix, et al.
Publicado: (2022)

Overexpressing high levels of human vaspin limits high fat diet-induced obesity and enhances energy expenditure in a transgenic mouse
por: Rapöhn, Inka, et al.
Publicado: (2023)

MicroRNA Expression in Human Omental and Subcutaneous Adipose Tissue
por: Klöting, Nora, et al.
Publicado: (2009)

Identification of Adipokine Clusters Related to Parameters of Fat Mass, Insulin Sensitivity and Inflammation
por: Flehmig, Gesine, et al.
Publicado: (2014)

Treatment-Induced Neuropathy in Diabetes (TIND)—Developing a Disease Model in Type 1 Diabetic Rats
por: Baum, Petra, et al.
Publicado: (2021)

Analysis of Human TAAR8 and Murine Taar8b Mediated Signaling Pathways and Expression Profile
por: Mühlhaus, Jessica, et al.
Publicado: (2014)

Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth
por: Klöting, Nora, et al.
Publicado: (2008)

Linagliptin Improves Insulin Sensitivity and Hepatic Steatosis in Diet-Induced Obesity
por: Kern, Matthias, et al.
Publicado: (2012)

Adipose Stromal Cell Expansion and Exhaustion: Mechanisms and Consequences
por: Eckel-Mahan, Kristin, et al.
Publicado: (2020)

p8 deficiency leads to elevated pancreatic beta cell mass but does not contribute to insulin resistance in mice fed with high-fat diet
por: Hollenbach, Marcus, et al.
Publicado: (2018)

A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Lepr(db/db) mice
por: Berger, Claudia, et al.
Publicado: (2021)

A novel thermoregulatory role for PDE10A in mouse and human adipocytes
por: Hankir, Mohammed K, et al.
Publicado: (2016)

Identification of distinct transcriptome signatures of human adipose tissue from fifteen depots
por: Schleinitz, Dorit, et al.
Publicado: (2020)

Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells
por: Kern, Ursula, et al.
Publicado: (2015)

Associations between vitamin D, immunoglobulin E concentrations, and obesity
por: Avila Castillo, Angelica, et al.
Publicado: (2023)

A Systematic Evaluation of Semispecific Peptide Search Parameter Enables Identification of Previously Undescribed N-Terminal Peptides and Conserved Proteolytic Processing in Cancer Cell Lines
por: Fahrner, Matthias, et al.
Publicado: (2021)

Two Patterns of Adipokine and Other Biomarker Dynamics in a Long-Term Weight Loss Intervention
por: Blüher, Matthias, et al.
Publicado: (2012)

ADCY5 Gene Expression in Adipose Tissue Is Related to Obesity in Men and Mice
por: Knigge, Anja, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_aph2psd9aa1rrq5mc1vaqmss4n