Cargando…

Phosphorylation of Microglial IRF5 and IRF4 by IRAK4 Regulates Inflammatory Responses to Ischemia

Background: Interferon Regulatory Factor (IRF) 5 and 4 play a determinant role in regulating microglial pro- and anti-inflammatory responses to cerebral ischemia. How microglial IRF5 and IRF4 signaling are activated has been elusive. We hypothesized that interleukin-1 receptor associated kinase 4 (I...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ngwa, Conelius, Mamun, Abdullah Al, Xu, Yan, Sharmeen, Romana, Liu, Fudong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912637/ https://www.ncbi.nlm.nih.gov/pubmed/33573200 http://dx.doi.org/10.3390/cells10020276

Ejemplares similares

Regulation of microglial activation in stroke in aged mice: a translational study
por: Ngwa, Conelius, et al.
Publicado: (2022)

Interferon regulatory factor 4/5 signaling impacts on microglial activation after ischemic stroke in mice
por: Al Mamun, Abdullah, et al.
Publicado: (2018)

X chromosome escapee genes are involved in ischemic sexual dimorphism through epigenetic modification of inflammatory signals
por: Qi, Shaohua, et al.
Publicado: (2021)

IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus
por: Manni, Michela, et al.
Publicado: (2015)

Swine IRF3/IRF7 attenuates inflammatory responses through TLR4 signaling pathway
por: Chen, Pei-Ge, et al.
Publicado: (2017)

IRF3 and IRF7 mediate neovascularization via inflammatory cytokines
por: Simons, Karin H., et al.
Publicado: (2019)

DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation
por: Andrilenas, Kellen K, et al.
Publicado: (2018)

Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization
por: Dalskov, Louise, et al.
Publicado: (2020)

Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
por: Campos Carrascosa, Lucia, et al.
Publicado: (2017)

Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development
por: Yamamoto, Michio, et al.
Publicado: (2011)

Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming
por: McDaniel, Margaret M., et al.
Publicado: (2020)

TRIM14 expression is regulated by IRF‐1 and IRF‐2
por: Cui, Jingang, et al.
Publicado: (2019)

DJ-1 Regulates Microglial Polarization Through P62-Mediated TRAF6/IRF5 Signaling in Cerebral Ischemia-Reperfusion
por: Wang, Tingting, et al.
Publicado: (2020)

Inflammatory Responses are Sex Specific in Chronic Hypoxic–Ischemic Encephalopathy
por: Al Mamun, Abdullah, et al.
Publicado: (2018)

IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling
por: Lazear, Helen M., et al.
Publicado: (2013)

IRF4 as an Oncogenic Master Transcription Factor
por: Wong, Regina Wan Ju, et al.
Publicado: (2022)

Transcriptional reprogramming by mutated IRF4 in lymphoma
por: Schleussner, Nikolai, et al.
Publicado: (2023)

Correction: IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling
por: Lazear, Helen M., et al.
Publicado: (2013)

Phosphorylation of interferon regulatory factor 9 (IRF9)
por: Paul, Alvin, et al.
Publicado: (2023)

Regulation of Lymphocyte Apoptosis by Interferon Regulatory Factor 4 (IRF-4)
por: Fanzo, Jessica C., et al.
Publicado: (2003)

An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells
por: Davies, James, et al.
Publicado: (2021)

Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation
por: Ryzhakov, Grigory, et al.
Publicado: (2021)

IRF5 Is a Specific Marker of Inflammatory Macrophages In Vivo
por: Weiss, Miriam, et al.
Publicado: (2013)

IRF5 gene polymorphisms in melanoma
por: Uccellini, Lorenzo, et al.
Publicado: (2012)

IRF4 haploinsufficiency in a family with Whipple’s disease
por: Guérin, Antoine, et al.
Publicado: (2018)

Structural determinants of the IRF4/DNA homodimeric complex
por: Sundararaj, Srinivasan, et al.
Publicado: (2021)

Human inborn errors of immunity associated with IRF4
por: Thouenon, Romane, et al.
Publicado: (2023)

The dynamic functions of IRF4 in B cell malignancies
por: Maffei, Rossana, et al.
Publicado: (2022)

The Eukaryotic Translation Initiation Factor 4F Complex Restricts Rotavirus Infection via Regulating the Expression of IRF1 and IRF7
por: Chen, Sunrui, et al.
Publicado: (2019)

Scoparone Inhibits LPS-Simulated Inflammatory Response by Suppressing IRF3 and ERK in BV-2 Microglial Cells
por: Cho, Duk-Yeon, et al.
Publicado: (2016)

IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages
por: Saliba, David G., et al.
Publicado: (2014)

Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition
por: Zhou, Nan, et al.
Publicado: (2018)

IRF4b and IRF8 Negatively Regulate RLR-Mediated NF-κB Signaling by Targeting MITA for Degradation in Teleost Fish
por: Yan, Xiaolong, et al.
Publicado: (2022)

IRF5 regulates airway macrophage metabolic responses
por: Albers, G. J., et al.
Publicado: (2021)

Epigenetic Silencing of IRF7 and/or IRF5 in Lung Cancer Cells Leads to Increased Sensitivity to Oncolytic Viruses
por: Li, Qunfang, et al.
Publicado: (2011)

BATF-JUN is critical for IRF4-mediated transcription in T cells
por: Li, Peng, et al.
Publicado: (2012)

Role of IRF4 in the Protection of Metformin-Mediated Sepsis Myocarditis
por: Li, Minghua, et al.
Publicado: (2019)

Genomic programming of IRF4-expressing human Langerhans cells
por: Sirvent, Sofia, et al.
Publicado: (2020)

Identification and antiviral effect of Cherry Valley duck IRF4
por: Zhai, Xinyu, et al.
Publicado: (2021)

Regulatory effects of IRF4 on immune cells in the tumor microenvironment
por: Lu, Jing, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ugdmeke1gofdq29p8pf1c8qmsc