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Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review

Aminoglycoside or colistin therapy may alter the renal tubular function without decreasing the glomerular filtration rate. This association has never been extensively investigated. We conducted a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and M...

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Autores principales: Scoglio, Martin, Bronz, Gabriel, Rinoldi, Pietro O., Faré, Pietro B., Betti, Céline, Bianchetti, Mario G., Simonetti, Giacomo D., Gennaro, Viola, Renzi, Samuele, Lava, Sebastiano A. G., Milani, Gregorio P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912654/
https://www.ncbi.nlm.nih.gov/pubmed/33535401
http://dx.doi.org/10.3390/antibiotics10020140
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author Scoglio, Martin
Bronz, Gabriel
Rinoldi, Pietro O.
Faré, Pietro B.
Betti, Céline
Bianchetti, Mario G.
Simonetti, Giacomo D.
Gennaro, Viola
Renzi, Samuele
Lava, Sebastiano A. G.
Milani, Gregorio P.
author_facet Scoglio, Martin
Bronz, Gabriel
Rinoldi, Pietro O.
Faré, Pietro B.
Betti, Céline
Bianchetti, Mario G.
Simonetti, Giacomo D.
Gennaro, Viola
Renzi, Samuele
Lava, Sebastiano A. G.
Milani, Gregorio P.
author_sort Scoglio, Martin
collection PubMed
description Aminoglycoside or colistin therapy may alter the renal tubular function without decreasing the glomerular filtration rate. This association has never been extensively investigated. We conducted a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. Databases searched included United States National Library of Medicine, Excerpta Medica, and Web of Science. For the final analysis, we evaluated 46 reports, published after 1960, describing 82 cases. A total of 286 electrolyte and acid-base disorders were reported. Hypomagnesemia, hypokalemia, and hypocalcemia were reported in more than three quarter of cases. Further disorders were, in decreasing order of frequency, metabolic alkalosis, hyponatremia, hypophosphatemia, hypouricemia, hypernatremia, and metabolic acidosis. Six electrolyte and acid-base disorders were reported in seven cases, five in 12 cases, four in 16 cases, three in 31 cases, two in 11 cases, and one in five cases. Laboratory features consistent with a loop of Henle/distal tubular dysfunction were noted in 56 (68%), with a proximal tubular dysfunction in three (3.7%), and with a mixed dysfunction in five (6.1%) cases. The laboratory abnormality was unclassified in the remaining 18 (22%) cases. Treatment with aminoglycosides or colistin may trigger a proximal tubular or, more frequently, a loop of Henle/distal tubular dysfunction.
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spelling pubmed-79126542021-02-28 Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review Scoglio, Martin Bronz, Gabriel Rinoldi, Pietro O. Faré, Pietro B. Betti, Céline Bianchetti, Mario G. Simonetti, Giacomo D. Gennaro, Viola Renzi, Samuele Lava, Sebastiano A. G. Milani, Gregorio P. Antibiotics (Basel) Review Aminoglycoside or colistin therapy may alter the renal tubular function without decreasing the glomerular filtration rate. This association has never been extensively investigated. We conducted a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. Databases searched included United States National Library of Medicine, Excerpta Medica, and Web of Science. For the final analysis, we evaluated 46 reports, published after 1960, describing 82 cases. A total of 286 electrolyte and acid-base disorders were reported. Hypomagnesemia, hypokalemia, and hypocalcemia were reported in more than three quarter of cases. Further disorders were, in decreasing order of frequency, metabolic alkalosis, hyponatremia, hypophosphatemia, hypouricemia, hypernatremia, and metabolic acidosis. Six electrolyte and acid-base disorders were reported in seven cases, five in 12 cases, four in 16 cases, three in 31 cases, two in 11 cases, and one in five cases. Laboratory features consistent with a loop of Henle/distal tubular dysfunction were noted in 56 (68%), with a proximal tubular dysfunction in three (3.7%), and with a mixed dysfunction in five (6.1%) cases. The laboratory abnormality was unclassified in the remaining 18 (22%) cases. Treatment with aminoglycosides or colistin may trigger a proximal tubular or, more frequently, a loop of Henle/distal tubular dysfunction. MDPI 2021-02-01 /pmc/articles/PMC7912654/ /pubmed/33535401 http://dx.doi.org/10.3390/antibiotics10020140 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Scoglio, Martin
Bronz, Gabriel
Rinoldi, Pietro O.
Faré, Pietro B.
Betti, Céline
Bianchetti, Mario G.
Simonetti, Giacomo D.
Gennaro, Viola
Renzi, Samuele
Lava, Sebastiano A. G.
Milani, Gregorio P.
Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review
title Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review
title_full Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review
title_fullStr Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review
title_full_unstemmed Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review
title_short Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review
title_sort electrolyte and acid-base disorders triggered by aminoglycoside or colistin therapy: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912654/
https://www.ncbi.nlm.nih.gov/pubmed/33535401
http://dx.doi.org/10.3390/antibiotics10020140
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