Cargando…

The Prevalence and Clinical Significance of Anaerobic Bacteria in Major Liver Resection

(1) Background: Anaerobic infections in hepatobiliary surgery have rarely been addressed. Whereas infectious complications during the perioperative phase of liver resections are common, there are very limited data on the prevalence and clinical role of anaerobes in this context. Given the risk of co...

Descripción completa

Detalles Bibliográficos
Autores principales: Strohäker, Jens, Bareiß, Sophia, Nadalin, Silvio, Königsrainer, Alfred, Ladurner, Ruth, Meier, Anke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912677/
https://www.ncbi.nlm.nih.gov/pubmed/33572541
http://dx.doi.org/10.3390/antibiotics10020139
_version_ 1783656630651453440
author Strohäker, Jens
Bareiß, Sophia
Nadalin, Silvio
Königsrainer, Alfred
Ladurner, Ruth
Meier, Anke
author_facet Strohäker, Jens
Bareiß, Sophia
Nadalin, Silvio
Königsrainer, Alfred
Ladurner, Ruth
Meier, Anke
author_sort Strohäker, Jens
collection PubMed
description (1) Background: Anaerobic infections in hepatobiliary surgery have rarely been addressed. Whereas infectious complications during the perioperative phase of liver resections are common, there are very limited data on the prevalence and clinical role of anaerobes in this context. Given the risk of contaminated bile in liver resections, the goal of our study was to investigate the prevalence and outcome of anaerobic infections in major hepatectomies. (2) Methods: We retrospectively analyzed the charts of 245 consecutive major hepatectomies that were performed at the department of General, Visceral, and Transplantation Surgery of the University Hospital of Tuebingen between July 2017 and August 2020. All microbiological cultures were screened for the prevalence of anaerobic bacteria and the patients’ clinical characteristics and outcomes were evaluated. (3) Results: Of the 245 patients, 13 patients suffered from anaerobic infections. Seven had positive cultures from the biliary tract during the primary procedure, while six had positive culture results from samples obtained during the management of complications. Risk factors for anaerobic infections were preoperative biliary stenting (p = 0.002) and bile leaks (p = 0.009). All of these infections had to be treated by intervention and adjunct antibiotic treatment with broad spectrum antibiotics. (4) Conclusions: Anaerobic infections are rare in liver resections. Certain risk factors trigger the antibiotic coverage of anaerobes.
format Online
Article
Text
id pubmed-7912677
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79126772021-02-28 The Prevalence and Clinical Significance of Anaerobic Bacteria in Major Liver Resection Strohäker, Jens Bareiß, Sophia Nadalin, Silvio Königsrainer, Alfred Ladurner, Ruth Meier, Anke Antibiotics (Basel) Article (1) Background: Anaerobic infections in hepatobiliary surgery have rarely been addressed. Whereas infectious complications during the perioperative phase of liver resections are common, there are very limited data on the prevalence and clinical role of anaerobes in this context. Given the risk of contaminated bile in liver resections, the goal of our study was to investigate the prevalence and outcome of anaerobic infections in major hepatectomies. (2) Methods: We retrospectively analyzed the charts of 245 consecutive major hepatectomies that were performed at the department of General, Visceral, and Transplantation Surgery of the University Hospital of Tuebingen between July 2017 and August 2020. All microbiological cultures were screened for the prevalence of anaerobic bacteria and the patients’ clinical characteristics and outcomes were evaluated. (3) Results: Of the 245 patients, 13 patients suffered from anaerobic infections. Seven had positive cultures from the biliary tract during the primary procedure, while six had positive culture results from samples obtained during the management of complications. Risk factors for anaerobic infections were preoperative biliary stenting (p = 0.002) and bile leaks (p = 0.009). All of these infections had to be treated by intervention and adjunct antibiotic treatment with broad spectrum antibiotics. (4) Conclusions: Anaerobic infections are rare in liver resections. Certain risk factors trigger the antibiotic coverage of anaerobes. MDPI 2021-01-31 /pmc/articles/PMC7912677/ /pubmed/33572541 http://dx.doi.org/10.3390/antibiotics10020139 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Strohäker, Jens
Bareiß, Sophia
Nadalin, Silvio
Königsrainer, Alfred
Ladurner, Ruth
Meier, Anke
The Prevalence and Clinical Significance of Anaerobic Bacteria in Major Liver Resection
title The Prevalence and Clinical Significance of Anaerobic Bacteria in Major Liver Resection
title_full The Prevalence and Clinical Significance of Anaerobic Bacteria in Major Liver Resection
title_fullStr The Prevalence and Clinical Significance of Anaerobic Bacteria in Major Liver Resection
title_full_unstemmed The Prevalence and Clinical Significance of Anaerobic Bacteria in Major Liver Resection
title_short The Prevalence and Clinical Significance of Anaerobic Bacteria in Major Liver Resection
title_sort prevalence and clinical significance of anaerobic bacteria in major liver resection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912677/
https://www.ncbi.nlm.nih.gov/pubmed/33572541
http://dx.doi.org/10.3390/antibiotics10020139
work_keys_str_mv AT strohakerjens theprevalenceandclinicalsignificanceofanaerobicbacteriainmajorliverresection
AT bareißsophia theprevalenceandclinicalsignificanceofanaerobicbacteriainmajorliverresection
AT nadalinsilvio theprevalenceandclinicalsignificanceofanaerobicbacteriainmajorliverresection
AT konigsraineralfred theprevalenceandclinicalsignificanceofanaerobicbacteriainmajorliverresection
AT ladurnerruth theprevalenceandclinicalsignificanceofanaerobicbacteriainmajorliverresection
AT meieranke theprevalenceandclinicalsignificanceofanaerobicbacteriainmajorliverresection
AT strohakerjens prevalenceandclinicalsignificanceofanaerobicbacteriainmajorliverresection
AT bareißsophia prevalenceandclinicalsignificanceofanaerobicbacteriainmajorliverresection
AT nadalinsilvio prevalenceandclinicalsignificanceofanaerobicbacteriainmajorliverresection
AT konigsraineralfred prevalenceandclinicalsignificanceofanaerobicbacteriainmajorliverresection
AT ladurnerruth prevalenceandclinicalsignificanceofanaerobicbacteriainmajorliverresection
AT meieranke prevalenceandclinicalsignificanceofanaerobicbacteriainmajorliverresection