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Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs
Hernia is one of the most common defects in pigs. The most prevalent are the scrotal (SH), inguinal (IH) and umbilical (UH) hernias. We compared the inguinal ring transcriptome of normal and SH-affected pigs with the umbilical ring transcriptome of normal and UH-affected pigs to discover genes and p...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912685/ https://www.ncbi.nlm.nih.gov/pubmed/33513662 http://dx.doi.org/10.3390/genes12020166 |
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author | Rodrigues, Ariene Fernanda Grando Ibelli, Adriana Mércia Guaratini Peixoto, Jane de Oliveira Cantão, Maurício Egídio de Oliveira, Haniel Cedraz Savoldi, Igor Ricardo Souza, Mayla Regina Mores, Marcos Antônio Zanella Carreño, Luis Orlando Duitama Ledur, Mônica Corrêa |
author_facet | Rodrigues, Ariene Fernanda Grando Ibelli, Adriana Mércia Guaratini Peixoto, Jane de Oliveira Cantão, Maurício Egídio de Oliveira, Haniel Cedraz Savoldi, Igor Ricardo Souza, Mayla Regina Mores, Marcos Antônio Zanella Carreño, Luis Orlando Duitama Ledur, Mônica Corrêa |
author_sort | Rodrigues, Ariene Fernanda Grando |
collection | PubMed |
description | Hernia is one of the most common defects in pigs. The most prevalent are the scrotal (SH), inguinal (IH) and umbilical (UH) hernias. We compared the inguinal ring transcriptome of normal and SH-affected pigs with the umbilical ring transcriptome of normal and UH-affected pigs to discover genes and pathways involved with the development of both types of hernia. A total of 13,307 transcripts was expressed in the inguinal and 13,302 in the umbilical ring tissues with 94.91% of them present in both tissues. From those, 35 genes were differentially expressed in both groups, participating in 108 biological processes. A total of 67 polymorphisms was identified in the inguinal ring and 76 in the umbilical ring tissue, of which 11 and 14 were novel, respectively. A single nucleotide polymorphism (SNP) with deleterious function was identified in the integrin α M (ITGAM) gene. The microtubule associated protein 1 light chain 3 γ (MAP1LC3C), vitrin (VIT), aggrecan (ACAN), alkaline ceramidase 2 (ACER2), potassium calcium-activated channel subfamily M α 1 (KCNMA1) and synaptopodin 2 (SYNPO2) genes are highlighted as candidates to trigger both types of hernia. We generated the first comparative study of the pig umbilical and inguinal ring transcriptomes, contributing to the understanding of the genetic mechanism involved with these two types of hernia in pigs and probably in other mammals. |
format | Online Article Text |
id | pubmed-7912685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79126852021-02-28 Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs Rodrigues, Ariene Fernanda Grando Ibelli, Adriana Mércia Guaratini Peixoto, Jane de Oliveira Cantão, Maurício Egídio de Oliveira, Haniel Cedraz Savoldi, Igor Ricardo Souza, Mayla Regina Mores, Marcos Antônio Zanella Carreño, Luis Orlando Duitama Ledur, Mônica Corrêa Genes (Basel) Article Hernia is one of the most common defects in pigs. The most prevalent are the scrotal (SH), inguinal (IH) and umbilical (UH) hernias. We compared the inguinal ring transcriptome of normal and SH-affected pigs with the umbilical ring transcriptome of normal and UH-affected pigs to discover genes and pathways involved with the development of both types of hernia. A total of 13,307 transcripts was expressed in the inguinal and 13,302 in the umbilical ring tissues with 94.91% of them present in both tissues. From those, 35 genes were differentially expressed in both groups, participating in 108 biological processes. A total of 67 polymorphisms was identified in the inguinal ring and 76 in the umbilical ring tissue, of which 11 and 14 were novel, respectively. A single nucleotide polymorphism (SNP) with deleterious function was identified in the integrin α M (ITGAM) gene. The microtubule associated protein 1 light chain 3 γ (MAP1LC3C), vitrin (VIT), aggrecan (ACAN), alkaline ceramidase 2 (ACER2), potassium calcium-activated channel subfamily M α 1 (KCNMA1) and synaptopodin 2 (SYNPO2) genes are highlighted as candidates to trigger both types of hernia. We generated the first comparative study of the pig umbilical and inguinal ring transcriptomes, contributing to the understanding of the genetic mechanism involved with these two types of hernia in pigs and probably in other mammals. MDPI 2021-01-27 /pmc/articles/PMC7912685/ /pubmed/33513662 http://dx.doi.org/10.3390/genes12020166 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rodrigues, Ariene Fernanda Grando Ibelli, Adriana Mércia Guaratini Peixoto, Jane de Oliveira Cantão, Maurício Egídio de Oliveira, Haniel Cedraz Savoldi, Igor Ricardo Souza, Mayla Regina Mores, Marcos Antônio Zanella Carreño, Luis Orlando Duitama Ledur, Mônica Corrêa Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs |
title | Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs |
title_full | Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs |
title_fullStr | Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs |
title_full_unstemmed | Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs |
title_short | Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs |
title_sort | genes and snps involved with scrotal and umbilical hernia in pigs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912685/ https://www.ncbi.nlm.nih.gov/pubmed/33513662 http://dx.doi.org/10.3390/genes12020166 |
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