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Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes

Xeroderma is induced by diabetes, reducing patients’ quality of life. We aimed to clarify the roles of cutaneous water channel aquaporin-3 (AQP3) in diabetic xeroderma using type 2 diabetes model db/db mice. Blood glucose levels were unchanged in 5-week-old db/db mice compared to db/+ mice (control...

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Autores principales: Ikarashi, Nobutomo, Mizukami, Nanaho, Pei, Chenchen, Uchino, Ryogo, Fujisawa, Izumi, Fukuda, Natsuko, Kon, Risako, Sakai, Hiroyasu, Kamei, Junzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912687/
https://www.ncbi.nlm.nih.gov/pubmed/33494453
http://dx.doi.org/10.3390/biomedicines9020104
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author Ikarashi, Nobutomo
Mizukami, Nanaho
Pei, Chenchen
Uchino, Ryogo
Fujisawa, Izumi
Fukuda, Natsuko
Kon, Risako
Sakai, Hiroyasu
Kamei, Junzo
author_facet Ikarashi, Nobutomo
Mizukami, Nanaho
Pei, Chenchen
Uchino, Ryogo
Fujisawa, Izumi
Fukuda, Natsuko
Kon, Risako
Sakai, Hiroyasu
Kamei, Junzo
author_sort Ikarashi, Nobutomo
collection PubMed
description Xeroderma is induced by diabetes, reducing patients’ quality of life. We aimed to clarify the roles of cutaneous water channel aquaporin-3 (AQP3) in diabetic xeroderma using type 2 diabetes model db/db mice. Blood glucose levels were unchanged in 5-week-old db/db mice compared to db/+ mice (control mice), but the pathophysiology of type 2 diabetes was confirmed in 12-week-old db/db mice. The dermal water content and AQP3 expression in 5-week-old db/db mice were almost the same as those in the control mice. On the other hand, in 12-week-old db/db mice, the dermal water content and AQP3 expression were significantly decreased. The addition of glucose to HaCaT cells had no effect on AQP3, but tumor necrosis factor-α (TNF-α) decreased the AQP3 expression level. Blood TNF-α levels or skin inflammation markers in the 12-week-old db/db mice were significantly higher than those in control mice. AQP3 levels in the skin were decreased in type 2 diabetes, and this decrease in AQP3 may be one of the causes of xeroderma. Therefore, a substance that increases AQP3 may be useful for improving xeroderma. Additionally, a decrease in skin AQP3 may be triggered by inflammation. Therefore, anti-inflammatory drugs may be effective as new therapeutic agents for diabetic xerosis.
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spelling pubmed-79126872021-02-28 Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes Ikarashi, Nobutomo Mizukami, Nanaho Pei, Chenchen Uchino, Ryogo Fujisawa, Izumi Fukuda, Natsuko Kon, Risako Sakai, Hiroyasu Kamei, Junzo Biomedicines Article Xeroderma is induced by diabetes, reducing patients’ quality of life. We aimed to clarify the roles of cutaneous water channel aquaporin-3 (AQP3) in diabetic xeroderma using type 2 diabetes model db/db mice. Blood glucose levels were unchanged in 5-week-old db/db mice compared to db/+ mice (control mice), but the pathophysiology of type 2 diabetes was confirmed in 12-week-old db/db mice. The dermal water content and AQP3 expression in 5-week-old db/db mice were almost the same as those in the control mice. On the other hand, in 12-week-old db/db mice, the dermal water content and AQP3 expression were significantly decreased. The addition of glucose to HaCaT cells had no effect on AQP3, but tumor necrosis factor-α (TNF-α) decreased the AQP3 expression level. Blood TNF-α levels or skin inflammation markers in the 12-week-old db/db mice were significantly higher than those in control mice. AQP3 levels in the skin were decreased in type 2 diabetes, and this decrease in AQP3 may be one of the causes of xeroderma. Therefore, a substance that increases AQP3 may be useful for improving xeroderma. Additionally, a decrease in skin AQP3 may be triggered by inflammation. Therefore, anti-inflammatory drugs may be effective as new therapeutic agents for diabetic xerosis. MDPI 2021-01-21 /pmc/articles/PMC7912687/ /pubmed/33494453 http://dx.doi.org/10.3390/biomedicines9020104 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ikarashi, Nobutomo
Mizukami, Nanaho
Pei, Chenchen
Uchino, Ryogo
Fujisawa, Izumi
Fukuda, Natsuko
Kon, Risako
Sakai, Hiroyasu
Kamei, Junzo
Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes
title Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes
title_full Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes
title_fullStr Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes
title_full_unstemmed Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes
title_short Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes
title_sort role of cutaneous aquaporins in the development of xeroderma in type 2 diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912687/
https://www.ncbi.nlm.nih.gov/pubmed/33494453
http://dx.doi.org/10.3390/biomedicines9020104
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