Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization

Both SARS-CoV-2 infections and vaccines induce robust immune responses. Current data suggested that high neutralizing antibody titers with sustained Th1 responses might correlate with protection against viral transmission and disease development and severity. In addition, genetic and innate immune f...

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Detalles Bibliográficos
Autores principales: Sui, Yongjun, Bekele, Yonas, Berzofsky, Jay A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912691/
https://www.ncbi.nlm.nih.gov/pubmed/33573221
http://dx.doi.org/10.3390/pathogens10020138
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author Sui, Yongjun
Bekele, Yonas
Berzofsky, Jay A.
author_facet Sui, Yongjun
Bekele, Yonas
Berzofsky, Jay A.
author_sort Sui, Yongjun
collection PubMed
description Both SARS-CoV-2 infections and vaccines induce robust immune responses. Current data suggested that high neutralizing antibody titers with sustained Th1 responses might correlate with protection against viral transmission and disease development and severity. In addition, genetic and innate immune factors, including higher levels of type I interferons, as well as the induction of trained immunity and local mucosal immunity also contribute to lower risk of infection and amelioration of disease severity. The identification of immune correlates of protection will facilitate the development of effective vaccines and therapeutics strategies.
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spelling pubmed-79126912021-02-28 Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization Sui, Yongjun Bekele, Yonas Berzofsky, Jay A. Pathogens Review Both SARS-CoV-2 infections and vaccines induce robust immune responses. Current data suggested that high neutralizing antibody titers with sustained Th1 responses might correlate with protection against viral transmission and disease development and severity. In addition, genetic and innate immune factors, including higher levels of type I interferons, as well as the induction of trained immunity and local mucosal immunity also contribute to lower risk of infection and amelioration of disease severity. The identification of immune correlates of protection will facilitate the development of effective vaccines and therapeutics strategies. MDPI 2021-01-30 /pmc/articles/PMC7912691/ /pubmed/33573221 http://dx.doi.org/10.3390/pathogens10020138 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sui, Yongjun
Bekele, Yonas
Berzofsky, Jay A.
Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization
title Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization
title_full Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization
title_fullStr Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization
title_full_unstemmed Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization
title_short Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization
title_sort potential sars-cov-2 immune correlates of protection in infection and vaccine immunization
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912691/
https://www.ncbi.nlm.nih.gov/pubmed/33573221
http://dx.doi.org/10.3390/pathogens10020138
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