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Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma
Glaucoma is a leading cause of blindness worldwide. In glaucoma, a progressive dysfunction and death of retinal ganglion cells occurs, eliminating transfer of visual information to the brain. Currently, the only available therapies target the lowering of intraocular pressure, but many patients conti...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912764/ https://www.ncbi.nlm.nih.gov/pubmed/33535578 http://dx.doi.org/10.3390/cells10020295 |
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author | Tribble, James R. Hui, Flora Jöe, Melissa Bell, Katharina Chrysostomou, Vicki Crowston, Jonathan G. Williams, Pete A. |
author_facet | Tribble, James R. Hui, Flora Jöe, Melissa Bell, Katharina Chrysostomou, Vicki Crowston, Jonathan G. Williams, Pete A. |
author_sort | Tribble, James R. |
collection | PubMed |
description | Glaucoma is a leading cause of blindness worldwide. In glaucoma, a progressive dysfunction and death of retinal ganglion cells occurs, eliminating transfer of visual information to the brain. Currently, the only available therapies target the lowering of intraocular pressure, but many patients continue to lose vision. Emerging pre-clinical and clinical evidence suggests that metabolic deficiencies and defects may play an important role in glaucoma pathophysiology. While pre-clinical studies in animal models have begun to mechanistically uncover these metabolic changes, some existing clinical evidence already points to potential benefits in maintaining metabolic fitness. Modifying diet and exercise can be implemented by patients as an adjunct to intraocular pressure lowering, which may be of therapeutic benefit to retinal ganglion cells in glaucoma. |
format | Online Article Text |
id | pubmed-7912764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79127642021-02-28 Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma Tribble, James R. Hui, Flora Jöe, Melissa Bell, Katharina Chrysostomou, Vicki Crowston, Jonathan G. Williams, Pete A. Cells Review Glaucoma is a leading cause of blindness worldwide. In glaucoma, a progressive dysfunction and death of retinal ganglion cells occurs, eliminating transfer of visual information to the brain. Currently, the only available therapies target the lowering of intraocular pressure, but many patients continue to lose vision. Emerging pre-clinical and clinical evidence suggests that metabolic deficiencies and defects may play an important role in glaucoma pathophysiology. While pre-clinical studies in animal models have begun to mechanistically uncover these metabolic changes, some existing clinical evidence already points to potential benefits in maintaining metabolic fitness. Modifying diet and exercise can be implemented by patients as an adjunct to intraocular pressure lowering, which may be of therapeutic benefit to retinal ganglion cells in glaucoma. MDPI 2021-02-01 /pmc/articles/PMC7912764/ /pubmed/33535578 http://dx.doi.org/10.3390/cells10020295 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tribble, James R. Hui, Flora Jöe, Melissa Bell, Katharina Chrysostomou, Vicki Crowston, Jonathan G. Williams, Pete A. Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma |
title | Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma |
title_full | Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma |
title_fullStr | Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma |
title_full_unstemmed | Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma |
title_short | Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma |
title_sort | targeting diet and exercise for neuroprotection and neurorecovery in glaucoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912764/ https://www.ncbi.nlm.nih.gov/pubmed/33535578 http://dx.doi.org/10.3390/cells10020295 |
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