Mesothelin blockage by Amatuximab suppresses cell invasiveness, enhances gemcitabine sensitivity and regulates cancer cell stemness in mesothelin-positive pancreatic cancer cells

BACKGROUND: Mesothelin is a 40-kDa glycoprotein that is highly overexpressed in various types of cancers, however molecular mechanism of mesothelin has not been well-known. Amatuximab is a chimeric monoclonal IgG1/k antibody targeting mesothelin. We recently demonstrated that the combine therapy of...

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Detalles Bibliográficos
Autores principales: Matsuzawa, Fumihiko, Kamachi, Hirofumi, Mizukami, Tatsuzo, Einama, Takahiro, Kawamata, Futoshi, Fujii, Yuki, Fukai, Moto, Kobayashi, Nozomi, Hatanaka, Yutaka, Taketomi, Akinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912898/
https://www.ncbi.nlm.nih.gov/pubmed/33637083
http://dx.doi.org/10.1186/s12885-020-07722-3

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