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The value of lncRNAs as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis

BACKGROUND: In recent years, emerging studies have demonstrated critical functions and potential clinical applications of long non-coding RNA (lncRNA) in osteosarcoma. To further validate the prognostic value of multiple lncRNAs, we have conducted this updated meta-analysis. METHODS: Literature retr...

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Autores principales: Zhang, Wenchao, Ren, Xiaolei, Qi, Lin, Zhang, Chenghao, Tu, Chao, Li, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912917/
https://www.ncbi.nlm.nih.gov/pubmed/33639865
http://dx.doi.org/10.1186/s12885-021-07882-w
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author Zhang, Wenchao
Ren, Xiaolei
Qi, Lin
Zhang, Chenghao
Tu, Chao
Li, Zhihong
author_facet Zhang, Wenchao
Ren, Xiaolei
Qi, Lin
Zhang, Chenghao
Tu, Chao
Li, Zhihong
author_sort Zhang, Wenchao
collection PubMed
description BACKGROUND: In recent years, emerging studies have demonstrated critical functions and potential clinical applications of long non-coding RNA (lncRNA) in osteosarcoma. To further validate the prognostic value of multiple lncRNAs, we have conducted this updated meta-analysis. METHODS: Literature retrieval was conducted by searching PubMed, Web of Science and the Cochrane Library (last update by October 2, 2019). A meta-analysis was performed to explore association between lncRNAs expression and overall survival (OS) of osteosarcoma patients. Relationships between lncRNAs expression and other clinicopathological features were also analyzed respectively. RESULTS: Overall, 4351 patients from 62 studies were included in this meta-analysis and 25 lncRNAs were identified. Pooled analyses showed that high expression of 14 lncRNAs connoted worse OS, while two lncRNAs were associated with positive outcome. Further, analysis toward osteosarcoma clinicopathologic features demonstrated that overexpression of TUG1 and XIST indicated poor clinical parameters of patients. CONCLUSIONS: This meta-analysis has elucidated the prognostic potential of 16 lncRNAs in human osteosarcoma. Evidently, desperate expression and functional targets of these lncRNAs offer new approaches for prognosis and therapy of osteosarcoma. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-07882-w.
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spelling pubmed-79129172021-03-02 The value of lncRNAs as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis Zhang, Wenchao Ren, Xiaolei Qi, Lin Zhang, Chenghao Tu, Chao Li, Zhihong BMC Cancer Research Article BACKGROUND: In recent years, emerging studies have demonstrated critical functions and potential clinical applications of long non-coding RNA (lncRNA) in osteosarcoma. To further validate the prognostic value of multiple lncRNAs, we have conducted this updated meta-analysis. METHODS: Literature retrieval was conducted by searching PubMed, Web of Science and the Cochrane Library (last update by October 2, 2019). A meta-analysis was performed to explore association between lncRNAs expression and overall survival (OS) of osteosarcoma patients. Relationships between lncRNAs expression and other clinicopathological features were also analyzed respectively. RESULTS: Overall, 4351 patients from 62 studies were included in this meta-analysis and 25 lncRNAs were identified. Pooled analyses showed that high expression of 14 lncRNAs connoted worse OS, while two lncRNAs were associated with positive outcome. Further, analysis toward osteosarcoma clinicopathologic features demonstrated that overexpression of TUG1 and XIST indicated poor clinical parameters of patients. CONCLUSIONS: This meta-analysis has elucidated the prognostic potential of 16 lncRNAs in human osteosarcoma. Evidently, desperate expression and functional targets of these lncRNAs offer new approaches for prognosis and therapy of osteosarcoma. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-07882-w. BioMed Central 2021-02-27 /pmc/articles/PMC7912917/ /pubmed/33639865 http://dx.doi.org/10.1186/s12885-021-07882-w Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Zhang, Wenchao
Ren, Xiaolei
Qi, Lin
Zhang, Chenghao
Tu, Chao
Li, Zhihong
The value of lncRNAs as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis
title The value of lncRNAs as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis
title_full The value of lncRNAs as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis
title_fullStr The value of lncRNAs as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis
title_full_unstemmed The value of lncRNAs as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis
title_short The value of lncRNAs as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis
title_sort value of lncrnas as prognostic biomarkers on clinical outcomes in osteosarcoma: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912917/
https://www.ncbi.nlm.nih.gov/pubmed/33639865
http://dx.doi.org/10.1186/s12885-021-07882-w
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