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Two Distinct Faces of Vitamin C: AA vs. DHA

Historically, vitamin C has been associated with many regulatory processes that involve specific signaling pathways. Among the most studied signaling pathways are those involved in the regulation of aging, differentiation, neurotransmission, proliferation, and cell death processes in cancer. This wi...

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Autores principales: Ferrada, Luciano, Magdalena, Rocío, Barahona, María Jose, Ramírez, Eder, Sanzana, Cristian, Gutiérrez, José, Nualart, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912923/
https://www.ncbi.nlm.nih.gov/pubmed/33535710
http://dx.doi.org/10.3390/antiox10020215
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author Ferrada, Luciano
Magdalena, Rocío
Barahona, María Jose
Ramírez, Eder
Sanzana, Cristian
Gutiérrez, José
Nualart, Francisco
author_facet Ferrada, Luciano
Magdalena, Rocío
Barahona, María Jose
Ramírez, Eder
Sanzana, Cristian
Gutiérrez, José
Nualart, Francisco
author_sort Ferrada, Luciano
collection PubMed
description Historically, vitamin C has been associated with many regulatory processes that involve specific signaling pathways. Among the most studied signaling pathways are those involved in the regulation of aging, differentiation, neurotransmission, proliferation, and cell death processes in cancer. This wide variety of regulatory effects is due to the fact that vitamin C has a dual mechanism of action. On the one hand, it regulates the expression of genes associated with proliferation (Ccnf and Ccnb1), differentiation (Sox-2 and Oct-4), and cell death (RIPK1 and Bcl-2). At the same time, vitamin C can act as a regulator of kinases, such as MAPK and p38, or by controlling the activation of the NF-kB pathway, generating chronic responses related to changes in gene expression or acute responses associated with the regulation of signal transduction processes. To date, data from the literature show a permanent increase in processes regulated by vitamin C. In this review, we critically examine how vitamin C regulates these different cellular programs in normal and tumor cells.
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spelling pubmed-79129232021-02-28 Two Distinct Faces of Vitamin C: AA vs. DHA Ferrada, Luciano Magdalena, Rocío Barahona, María Jose Ramírez, Eder Sanzana, Cristian Gutiérrez, José Nualart, Francisco Antioxidants (Basel) Review Historically, vitamin C has been associated with many regulatory processes that involve specific signaling pathways. Among the most studied signaling pathways are those involved in the regulation of aging, differentiation, neurotransmission, proliferation, and cell death processes in cancer. This wide variety of regulatory effects is due to the fact that vitamin C has a dual mechanism of action. On the one hand, it regulates the expression of genes associated with proliferation (Ccnf and Ccnb1), differentiation (Sox-2 and Oct-4), and cell death (RIPK1 and Bcl-2). At the same time, vitamin C can act as a regulator of kinases, such as MAPK and p38, or by controlling the activation of the NF-kB pathway, generating chronic responses related to changes in gene expression or acute responses associated with the regulation of signal transduction processes. To date, data from the literature show a permanent increase in processes regulated by vitamin C. In this review, we critically examine how vitamin C regulates these different cellular programs in normal and tumor cells. MDPI 2021-02-01 /pmc/articles/PMC7912923/ /pubmed/33535710 http://dx.doi.org/10.3390/antiox10020215 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ferrada, Luciano
Magdalena, Rocío
Barahona, María Jose
Ramírez, Eder
Sanzana, Cristian
Gutiérrez, José
Nualart, Francisco
Two Distinct Faces of Vitamin C: AA vs. DHA
title Two Distinct Faces of Vitamin C: AA vs. DHA
title_full Two Distinct Faces of Vitamin C: AA vs. DHA
title_fullStr Two Distinct Faces of Vitamin C: AA vs. DHA
title_full_unstemmed Two Distinct Faces of Vitamin C: AA vs. DHA
title_short Two Distinct Faces of Vitamin C: AA vs. DHA
title_sort two distinct faces of vitamin c: aa vs. dha
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912923/
https://www.ncbi.nlm.nih.gov/pubmed/33535710
http://dx.doi.org/10.3390/antiox10020215
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