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Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling

In this study, we report the impact of the magnetic field on protein permeability through magnetic-responsive, block copolymer, nanocomposite membranes with hydrophilic and hydrophobic characters. The hydrophilic nanocomposite membranes were composed of spherical polymeric nanoparticles (NPs) synthe...

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Autores principales: Upadhyaya, Lakshmeesha, Semsarilar, Mona, Quemener, Damien, Fernández-Pacheco, Rodrigo, Martinez, Gema, Coelhoso, Isabel M., Nunes, Suzana P., Crespo, João G., Mallada, Reyes, Portugal, Carla A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912976/
https://www.ncbi.nlm.nih.gov/pubmed/33540798
http://dx.doi.org/10.3390/membranes11020105
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author Upadhyaya, Lakshmeesha
Semsarilar, Mona
Quemener, Damien
Fernández-Pacheco, Rodrigo
Martinez, Gema
Coelhoso, Isabel M.
Nunes, Suzana P.
Crespo, João G.
Mallada, Reyes
Portugal, Carla A. M.
author_facet Upadhyaya, Lakshmeesha
Semsarilar, Mona
Quemener, Damien
Fernández-Pacheco, Rodrigo
Martinez, Gema
Coelhoso, Isabel M.
Nunes, Suzana P.
Crespo, João G.
Mallada, Reyes
Portugal, Carla A. M.
author_sort Upadhyaya, Lakshmeesha
collection PubMed
description In this study, we report the impact of the magnetic field on protein permeability through magnetic-responsive, block copolymer, nanocomposite membranes with hydrophilic and hydrophobic characters. The hydrophilic nanocomposite membranes were composed of spherical polymeric nanoparticles (NPs) synthesized through polymerization-induced self-assembly (PISA) with iron oxide NPs coated with quaternized poly(2-dimethylamino)ethyl methacrylate. The hydrophobic nanocomposite membranes were prepared via nonsolvent-induced phase separation (NIPS) containing poly (methacrylic acid) and meso-2,3-dimercaptosuccinic acid-coated superparamagnetic nanoparticles (SPNPs). The permeation experiments were carried out using bovine serum albumin (BSA) as the model solute, in the absence of the magnetic field and under permanent and cyclic magnetic field conditions OFF/ON (strategy 1) and ON/OFF (strategy 2). It was observed that the magnetic field led to a lower reduction in the permeate fluxes of magnetic-responsive membranes during BSA permeation, regardless of the magnetic field strategy used, than that obtained in the absence of the magnetic field. Nevertheless, a comparative analysis of the effect caused by the two cyclic magnetic field strategies showed that strategy 2 allowed for a lower reduction of the original permeate fluxes during BSA permeation and higher protein sieving coefficients. Overall, these novel magneto-responsive block copolymer nanocomposite membranes proved to be competent in mitigating biofouling phenomena in bioseparation processes.
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spelling pubmed-79129762021-02-28 Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling Upadhyaya, Lakshmeesha Semsarilar, Mona Quemener, Damien Fernández-Pacheco, Rodrigo Martinez, Gema Coelhoso, Isabel M. Nunes, Suzana P. Crespo, João G. Mallada, Reyes Portugal, Carla A. M. Membranes (Basel) Article In this study, we report the impact of the magnetic field on protein permeability through magnetic-responsive, block copolymer, nanocomposite membranes with hydrophilic and hydrophobic characters. The hydrophilic nanocomposite membranes were composed of spherical polymeric nanoparticles (NPs) synthesized through polymerization-induced self-assembly (PISA) with iron oxide NPs coated with quaternized poly(2-dimethylamino)ethyl methacrylate. The hydrophobic nanocomposite membranes were prepared via nonsolvent-induced phase separation (NIPS) containing poly (methacrylic acid) and meso-2,3-dimercaptosuccinic acid-coated superparamagnetic nanoparticles (SPNPs). The permeation experiments were carried out using bovine serum albumin (BSA) as the model solute, in the absence of the magnetic field and under permanent and cyclic magnetic field conditions OFF/ON (strategy 1) and ON/OFF (strategy 2). It was observed that the magnetic field led to a lower reduction in the permeate fluxes of magnetic-responsive membranes during BSA permeation, regardless of the magnetic field strategy used, than that obtained in the absence of the magnetic field. Nevertheless, a comparative analysis of the effect caused by the two cyclic magnetic field strategies showed that strategy 2 allowed for a lower reduction of the original permeate fluxes during BSA permeation and higher protein sieving coefficients. Overall, these novel magneto-responsive block copolymer nanocomposite membranes proved to be competent in mitigating biofouling phenomena in bioseparation processes. MDPI 2021-02-02 /pmc/articles/PMC7912976/ /pubmed/33540798 http://dx.doi.org/10.3390/membranes11020105 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Upadhyaya, Lakshmeesha
Semsarilar, Mona
Quemener, Damien
Fernández-Pacheco, Rodrigo
Martinez, Gema
Coelhoso, Isabel M.
Nunes, Suzana P.
Crespo, João G.
Mallada, Reyes
Portugal, Carla A. M.
Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling
title Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling
title_full Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling
title_fullStr Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling
title_full_unstemmed Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling
title_short Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling
title_sort block copolymer-based magnetic mixed matrix membranes—effect of magnetic field on protein permeation and membrane fouling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912976/
https://www.ncbi.nlm.nih.gov/pubmed/33540798
http://dx.doi.org/10.3390/membranes11020105
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