Unravelling the Sequential Interplay of Mutational Mechanisms during Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia

Pediatric acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and is characterized by clonal heterogeneity. Genomic mutations can increase proliferative potential of leukemic cells and cause treatment resistance. However, mechanisms driving mutagenesis and clonal diversificati...

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Detalles Bibliográficos
Autores principales: Antić, Željko, Lelieveld, Stefan H., van der Ham, Cédric G., Sonneveld, Edwin, Hoogerbrugge, Peter M., Kuiper, Roland P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913080/
https://www.ncbi.nlm.nih.gov/pubmed/33540666
http://dx.doi.org/10.3390/genes12020214

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