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Combining Three Cohorts of World Trade Center Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality

Three cohorts including the Fire Department of the City of New York (FDNY), the World Trade Center Health Registry (WTCHR), and the General Responder Cohort (GRC), each funded by the World Trade Center Health Program have reported associations between WTC-exposures and cancer. Results have generally...

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Autores principales: Brackbill, Robert M., Kahn, Amy R., Li, Jiehui, Zeig-Owens, Rachel, Goldfarb, David G., Skerker, Molly, Farfel, Mark R., Cone, James E., Yung, Janette, Walker, Deborah J., Solomon, Adrienne, Qiao, Baozhen, Schymura, Maria J., Dasaro, Christopher R., Kristjansson, Dana, Webber, Mayris P., Lucchini, Roberto G., Todd, Andrew C., Prezant, David J., Boffetta, Paolo, Hall, Charles B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913216/
https://www.ncbi.nlm.nih.gov/pubmed/33546187
http://dx.doi.org/10.3390/ijerph18041386
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author Brackbill, Robert M.
Kahn, Amy R.
Li, Jiehui
Zeig-Owens, Rachel
Goldfarb, David G.
Skerker, Molly
Farfel, Mark R.
Cone, James E.
Yung, Janette
Walker, Deborah J.
Solomon, Adrienne
Qiao, Baozhen
Schymura, Maria J.
Dasaro, Christopher R.
Kristjansson, Dana
Webber, Mayris P.
Lucchini, Roberto G.
Todd, Andrew C.
Prezant, David J.
Boffetta, Paolo
Hall, Charles B.
author_facet Brackbill, Robert M.
Kahn, Amy R.
Li, Jiehui
Zeig-Owens, Rachel
Goldfarb, David G.
Skerker, Molly
Farfel, Mark R.
Cone, James E.
Yung, Janette
Walker, Deborah J.
Solomon, Adrienne
Qiao, Baozhen
Schymura, Maria J.
Dasaro, Christopher R.
Kristjansson, Dana
Webber, Mayris P.
Lucchini, Roberto G.
Todd, Andrew C.
Prezant, David J.
Boffetta, Paolo
Hall, Charles B.
author_sort Brackbill, Robert M.
collection PubMed
description Three cohorts including the Fire Department of the City of New York (FDNY), the World Trade Center Health Registry (WTCHR), and the General Responder Cohort (GRC), each funded by the World Trade Center Health Program have reported associations between WTC-exposures and cancer. Results have generally been consistent with effect estimates for excess incidence for all cancers ranging from 6 to 14% above background rates. Pooling would increase sample size and de-duplicate cases between the cohorts. However, pooling required time consuming steps: obtaining Institutional Review Board (IRB) approvals and legal agreements from entities involved; establishing an honest broker for managing the data; de-duplicating the pooled cohort files; applying to State Cancer Registries (SCRs) for matched cancer cases; and finalizing analysis data files. Obtaining SCR data use agreements ranged from 6.5 to 114.5 weeks with six states requiring >20 weeks. Records from FDNY (n = 16,221), WTCHR (n = 29,372), and GRC (n = 33,427) were combined de-duplicated resulting in 69,102 unique individuals. Overall, 7894 cancer tumors were matched to the pooled cohort, increasing the number cancers by as much as 58% compared to previous analyses. Pooling resulted in a coherent resource for future research for studies on rare cancers and mortality, with more representative of occupations and WTC- exposure.
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spelling pubmed-79132162021-02-28 Combining Three Cohorts of World Trade Center Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality Brackbill, Robert M. Kahn, Amy R. Li, Jiehui Zeig-Owens, Rachel Goldfarb, David G. Skerker, Molly Farfel, Mark R. Cone, James E. Yung, Janette Walker, Deborah J. Solomon, Adrienne Qiao, Baozhen Schymura, Maria J. Dasaro, Christopher R. Kristjansson, Dana Webber, Mayris P. Lucchini, Roberto G. Todd, Andrew C. Prezant, David J. Boffetta, Paolo Hall, Charles B. Int J Environ Res Public Health Article Three cohorts including the Fire Department of the City of New York (FDNY), the World Trade Center Health Registry (WTCHR), and the General Responder Cohort (GRC), each funded by the World Trade Center Health Program have reported associations between WTC-exposures and cancer. Results have generally been consistent with effect estimates for excess incidence for all cancers ranging from 6 to 14% above background rates. Pooling would increase sample size and de-duplicate cases between the cohorts. However, pooling required time consuming steps: obtaining Institutional Review Board (IRB) approvals and legal agreements from entities involved; establishing an honest broker for managing the data; de-duplicating the pooled cohort files; applying to State Cancer Registries (SCRs) for matched cancer cases; and finalizing analysis data files. Obtaining SCR data use agreements ranged from 6.5 to 114.5 weeks with six states requiring >20 weeks. Records from FDNY (n = 16,221), WTCHR (n = 29,372), and GRC (n = 33,427) were combined de-duplicated resulting in 69,102 unique individuals. Overall, 7894 cancer tumors were matched to the pooled cohort, increasing the number cancers by as much as 58% compared to previous analyses. Pooling resulted in a coherent resource for future research for studies on rare cancers and mortality, with more representative of occupations and WTC- exposure. MDPI 2021-02-03 /pmc/articles/PMC7913216/ /pubmed/33546187 http://dx.doi.org/10.3390/ijerph18041386 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Brackbill, Robert M.
Kahn, Amy R.
Li, Jiehui
Zeig-Owens, Rachel
Goldfarb, David G.
Skerker, Molly
Farfel, Mark R.
Cone, James E.
Yung, Janette
Walker, Deborah J.
Solomon, Adrienne
Qiao, Baozhen
Schymura, Maria J.
Dasaro, Christopher R.
Kristjansson, Dana
Webber, Mayris P.
Lucchini, Roberto G.
Todd, Andrew C.
Prezant, David J.
Boffetta, Paolo
Hall, Charles B.
Combining Three Cohorts of World Trade Center Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality
title Combining Three Cohorts of World Trade Center Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality
title_full Combining Three Cohorts of World Trade Center Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality
title_fullStr Combining Three Cohorts of World Trade Center Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality
title_full_unstemmed Combining Three Cohorts of World Trade Center Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality
title_short Combining Three Cohorts of World Trade Center Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality
title_sort combining three cohorts of world trade center rescue/recovery workers for assessing cancer incidence and mortality
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913216/
https://www.ncbi.nlm.nih.gov/pubmed/33546187
http://dx.doi.org/10.3390/ijerph18041386
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