The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders

Obesity is often associated with cognitive and mood disorders. Recent evidence suggests that obesity may cause hypothalamic inflammation. Our aim was to investigate the hypothesis that there is a causal link between obesity-induced hypothalamic inflammation and cognitive and mood disorders. Inflamma...

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Autores principales: Dionysopoulou, Sofia, Charmandari, Evangelia, Bargiota, Alexandra, Vlahos, Nikolaos F, Mastorakos, George, Valsamakis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913301/
https://www.ncbi.nlm.nih.gov/pubmed/33546219
http://dx.doi.org/10.3390/nu13020498
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author Dionysopoulou, Sofia
Charmandari, Evangelia
Bargiota, Alexandra
Vlahos, Nikolaos F
Mastorakos, George
Valsamakis, Georgios
author_facet Dionysopoulou, Sofia
Charmandari, Evangelia
Bargiota, Alexandra
Vlahos, Nikolaos F
Mastorakos, George
Valsamakis, Georgios
author_sort Dionysopoulou, Sofia
collection PubMed
description Obesity is often associated with cognitive and mood disorders. Recent evidence suggests that obesity may cause hypothalamic inflammation. Our aim was to investigate the hypothesis that there is a causal link between obesity-induced hypothalamic inflammation and cognitive and mood disorders. Inflammation may influence hypothalamic inter-connections with regions important for cognition and mood, while it may cause dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis and influence monoaminergic systems. Exercise, healthy diet, and glucagon-like peptide receptor agonists, which can reduce hypothalamic inflammation in obese models, could improve the deleterious effects on cognition and mood.
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spelling pubmed-79133012021-02-28 The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders Dionysopoulou, Sofia Charmandari, Evangelia Bargiota, Alexandra Vlahos, Nikolaos F Mastorakos, George Valsamakis, Georgios Nutrients Review Obesity is often associated with cognitive and mood disorders. Recent evidence suggests that obesity may cause hypothalamic inflammation. Our aim was to investigate the hypothesis that there is a causal link between obesity-induced hypothalamic inflammation and cognitive and mood disorders. Inflammation may influence hypothalamic inter-connections with regions important for cognition and mood, while it may cause dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis and influence monoaminergic systems. Exercise, healthy diet, and glucagon-like peptide receptor agonists, which can reduce hypothalamic inflammation in obese models, could improve the deleterious effects on cognition and mood. MDPI 2021-02-03 /pmc/articles/PMC7913301/ /pubmed/33546219 http://dx.doi.org/10.3390/nu13020498 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dionysopoulou, Sofia
Charmandari, Evangelia
Bargiota, Alexandra
Vlahos, Nikolaos F
Mastorakos, George
Valsamakis, Georgios
The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders
title The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders
title_full The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders
title_fullStr The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders
title_full_unstemmed The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders
title_short The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders
title_sort role of hypothalamic inflammation in diet-induced obesity and its association with cognitive and mood disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913301/
https://www.ncbi.nlm.nih.gov/pubmed/33546219
http://dx.doi.org/10.3390/nu13020498
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