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Validation of Candidate Phospholipid Biomarkers of Chronic Kidney Disease in Hyperglycemic Individuals and Their Organ-Specific Exploration in Leptin Receptor-Deficient db/db Mouse

Biological exploration of early biomarkers for chronic kidney disease (CKD) in (pre)diabetic individuals is crucial for personalized management of diabetes. Here, we evaluated two candidate biomarkers of incident CKD (sphingomyelin (SM) C18:1 and phosphatidylcholine diacyl (PC aa) C38:0) concerning...

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Autores principales: Huang, Jialing, Covic, Marcela, Huth, Cornelia, Rommel, Martina, Adam, Jonathan, Zukunft, Sven, Prehn, Cornelia, Wang, Li, Nano, Jana, Scheerer, Markus F., Neschen, Susanne, Kastenmüller, Gabi, Gieger, Christian, Laxy, Michael, Schliess, Freimut, Adamski, Jerzy, Suhre, Karsten, de Angelis, Martin Hrabe, Peters, Annette, Wang-Sattler, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913334/
https://www.ncbi.nlm.nih.gov/pubmed/33546276
http://dx.doi.org/10.3390/metabo11020089
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author Huang, Jialing
Covic, Marcela
Huth, Cornelia
Rommel, Martina
Adam, Jonathan
Zukunft, Sven
Prehn, Cornelia
Wang, Li
Nano, Jana
Scheerer, Markus F.
Neschen, Susanne
Kastenmüller, Gabi
Gieger, Christian
Laxy, Michael
Schliess, Freimut
Adamski, Jerzy
Suhre, Karsten
de Angelis, Martin Hrabe
Peters, Annette
Wang-Sattler, Rui
author_facet Huang, Jialing
Covic, Marcela
Huth, Cornelia
Rommel, Martina
Adam, Jonathan
Zukunft, Sven
Prehn, Cornelia
Wang, Li
Nano, Jana
Scheerer, Markus F.
Neschen, Susanne
Kastenmüller, Gabi
Gieger, Christian
Laxy, Michael
Schliess, Freimut
Adamski, Jerzy
Suhre, Karsten
de Angelis, Martin Hrabe
Peters, Annette
Wang-Sattler, Rui
author_sort Huang, Jialing
collection PubMed
description Biological exploration of early biomarkers for chronic kidney disease (CKD) in (pre)diabetic individuals is crucial for personalized management of diabetes. Here, we evaluated two candidate biomarkers of incident CKD (sphingomyelin (SM) C18:1 and phosphatidylcholine diacyl (PC aa) C38:0) concerning kidney function in hyperglycemic participants of the Cooperative Health Research in the Region of Augsburg (KORA) cohort, and in two biofluids and six organs of leptin receptor-deficient (db/db) mice and wild type controls. Higher serum concentrations of SM C18:1 and PC aa C38:0 in hyperglycemic individuals were found to be associated with lower estimated glomerular filtration rate (eGFR) and higher odds of CKD. In db/db mice, both metabolites had a significantly lower concentration in urine and adipose tissue, but higher in the lungs. Additionally, db/db mice had significantly higher SM C18:1 levels in plasma and liver, and PC aa C38:0 in adrenal glands. This cross-sectional human study confirms that SM C18:1 and PC aa C38:0 associate with kidney dysfunction in pre(diabetic) individuals, and the animal study suggests a potential implication of liver, lungs, adrenal glands, and visceral fat in their systemic regulation. Our results support further validation of the two phospholipids as early biomarkers of renal disease in patients with (pre)diabetes.
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spelling pubmed-79133342021-02-28 Validation of Candidate Phospholipid Biomarkers of Chronic Kidney Disease in Hyperglycemic Individuals and Their Organ-Specific Exploration in Leptin Receptor-Deficient db/db Mouse Huang, Jialing Covic, Marcela Huth, Cornelia Rommel, Martina Adam, Jonathan Zukunft, Sven Prehn, Cornelia Wang, Li Nano, Jana Scheerer, Markus F. Neschen, Susanne Kastenmüller, Gabi Gieger, Christian Laxy, Michael Schliess, Freimut Adamski, Jerzy Suhre, Karsten de Angelis, Martin Hrabe Peters, Annette Wang-Sattler, Rui Metabolites Article Biological exploration of early biomarkers for chronic kidney disease (CKD) in (pre)diabetic individuals is crucial for personalized management of diabetes. Here, we evaluated two candidate biomarkers of incident CKD (sphingomyelin (SM) C18:1 and phosphatidylcholine diacyl (PC aa) C38:0) concerning kidney function in hyperglycemic participants of the Cooperative Health Research in the Region of Augsburg (KORA) cohort, and in two biofluids and six organs of leptin receptor-deficient (db/db) mice and wild type controls. Higher serum concentrations of SM C18:1 and PC aa C38:0 in hyperglycemic individuals were found to be associated with lower estimated glomerular filtration rate (eGFR) and higher odds of CKD. In db/db mice, both metabolites had a significantly lower concentration in urine and adipose tissue, but higher in the lungs. Additionally, db/db mice had significantly higher SM C18:1 levels in plasma and liver, and PC aa C38:0 in adrenal glands. This cross-sectional human study confirms that SM C18:1 and PC aa C38:0 associate with kidney dysfunction in pre(diabetic) individuals, and the animal study suggests a potential implication of liver, lungs, adrenal glands, and visceral fat in their systemic regulation. Our results support further validation of the two phospholipids as early biomarkers of renal disease in patients with (pre)diabetes. MDPI 2021-02-03 /pmc/articles/PMC7913334/ /pubmed/33546276 http://dx.doi.org/10.3390/metabo11020089 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Jialing
Covic, Marcela
Huth, Cornelia
Rommel, Martina
Adam, Jonathan
Zukunft, Sven
Prehn, Cornelia
Wang, Li
Nano, Jana
Scheerer, Markus F.
Neschen, Susanne
Kastenmüller, Gabi
Gieger, Christian
Laxy, Michael
Schliess, Freimut
Adamski, Jerzy
Suhre, Karsten
de Angelis, Martin Hrabe
Peters, Annette
Wang-Sattler, Rui
Validation of Candidate Phospholipid Biomarkers of Chronic Kidney Disease in Hyperglycemic Individuals and Their Organ-Specific Exploration in Leptin Receptor-Deficient db/db Mouse
title Validation of Candidate Phospholipid Biomarkers of Chronic Kidney Disease in Hyperglycemic Individuals and Their Organ-Specific Exploration in Leptin Receptor-Deficient db/db Mouse
title_full Validation of Candidate Phospholipid Biomarkers of Chronic Kidney Disease in Hyperglycemic Individuals and Their Organ-Specific Exploration in Leptin Receptor-Deficient db/db Mouse
title_fullStr Validation of Candidate Phospholipid Biomarkers of Chronic Kidney Disease in Hyperglycemic Individuals and Their Organ-Specific Exploration in Leptin Receptor-Deficient db/db Mouse
title_full_unstemmed Validation of Candidate Phospholipid Biomarkers of Chronic Kidney Disease in Hyperglycemic Individuals and Their Organ-Specific Exploration in Leptin Receptor-Deficient db/db Mouse
title_short Validation of Candidate Phospholipid Biomarkers of Chronic Kidney Disease in Hyperglycemic Individuals and Their Organ-Specific Exploration in Leptin Receptor-Deficient db/db Mouse
title_sort validation of candidate phospholipid biomarkers of chronic kidney disease in hyperglycemic individuals and their organ-specific exploration in leptin receptor-deficient db/db mouse
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913334/
https://www.ncbi.nlm.nih.gov/pubmed/33546276
http://dx.doi.org/10.3390/metabo11020089
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