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Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival
Extra virgin olive oil (EVOO) is a major component of the Mediterranean diet and is appreciated worldwide because of its nutritional benefits in metabolic diseases, including type 2 diabetes (T2D). EVOO contains significant amounts of secondary metabolites, such as phenolic compounds (PCs), that may...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913337/ https://www.ncbi.nlm.nih.gov/pubmed/33546278 http://dx.doi.org/10.3390/plants10020286 |
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author | Marrano, Nicola Spagnuolo, Rosaria Biondi, Giuseppina Cignarelli, Angelo Perrini, Sebastio Vincenti, Leonardo Laviola, Luigi Giorgino, Francesco Natalicchio, Annalisa |
author_facet | Marrano, Nicola Spagnuolo, Rosaria Biondi, Giuseppina Cignarelli, Angelo Perrini, Sebastio Vincenti, Leonardo Laviola, Luigi Giorgino, Francesco Natalicchio, Annalisa |
author_sort | Marrano, Nicola |
collection | PubMed |
description | Extra virgin olive oil (EVOO) is a major component of the Mediterranean diet and is appreciated worldwide because of its nutritional benefits in metabolic diseases, including type 2 diabetes (T2D). EVOO contains significant amounts of secondary metabolites, such as phenolic compounds (PCs), that may positively influence the metabolic status. In this study, we investigated for the first time the effects of several PCs on beta-cell function and survival. To this aim, INS-1E cells were exposed to 10 μM of the main EVOO PCs for up to 24 h. Under these conditions, survival, insulin biosynthesis, glucose-stimulated insulin secretion (GSIS), and intracellular signaling activation (protein kinase B (AKT) and cAMP response element-binding protein (CREB)) were evaluated. Hydroxytyrosol, tyrosol, and apigenin augmented beta-cell proliferation and insulin biosynthesis, and apigenin and luteolin enhanced the GSIS. Conversely, vanillic acid and vanillin were pro-apoptotic for beta-cells, even if they increased the GSIS. In addition, oleuropein, p-coumaric, ferulic and sinapic acids significantly worsened the GSIS. Finally, a mixture of hydroxytyrosol, tyrosol, and apigenin promoted the GSIS in human pancreatic islets. Apigenin was the most effective compound and was also able to activate beneficial intracellular signaling. In conclusion, this study shows that hydroxytyrosol, tyrosol, and apigenin foster beta-cells’ health, suggesting that EVOO or supplements enriched with these compounds may improve insulin secretion and promote glycemic control in T2D patients. |
format | Online Article Text |
id | pubmed-7913337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79133372021-02-28 Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival Marrano, Nicola Spagnuolo, Rosaria Biondi, Giuseppina Cignarelli, Angelo Perrini, Sebastio Vincenti, Leonardo Laviola, Luigi Giorgino, Francesco Natalicchio, Annalisa Plants (Basel) Article Extra virgin olive oil (EVOO) is a major component of the Mediterranean diet and is appreciated worldwide because of its nutritional benefits in metabolic diseases, including type 2 diabetes (T2D). EVOO contains significant amounts of secondary metabolites, such as phenolic compounds (PCs), that may positively influence the metabolic status. In this study, we investigated for the first time the effects of several PCs on beta-cell function and survival. To this aim, INS-1E cells were exposed to 10 μM of the main EVOO PCs for up to 24 h. Under these conditions, survival, insulin biosynthesis, glucose-stimulated insulin secretion (GSIS), and intracellular signaling activation (protein kinase B (AKT) and cAMP response element-binding protein (CREB)) were evaluated. Hydroxytyrosol, tyrosol, and apigenin augmented beta-cell proliferation and insulin biosynthesis, and apigenin and luteolin enhanced the GSIS. Conversely, vanillic acid and vanillin were pro-apoptotic for beta-cells, even if they increased the GSIS. In addition, oleuropein, p-coumaric, ferulic and sinapic acids significantly worsened the GSIS. Finally, a mixture of hydroxytyrosol, tyrosol, and apigenin promoted the GSIS in human pancreatic islets. Apigenin was the most effective compound and was also able to activate beneficial intracellular signaling. In conclusion, this study shows that hydroxytyrosol, tyrosol, and apigenin foster beta-cells’ health, suggesting that EVOO or supplements enriched with these compounds may improve insulin secretion and promote glycemic control in T2D patients. MDPI 2021-02-03 /pmc/articles/PMC7913337/ /pubmed/33546278 http://dx.doi.org/10.3390/plants10020286 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Marrano, Nicola Spagnuolo, Rosaria Biondi, Giuseppina Cignarelli, Angelo Perrini, Sebastio Vincenti, Leonardo Laviola, Luigi Giorgino, Francesco Natalicchio, Annalisa Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival |
title | Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival |
title_full | Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival |
title_fullStr | Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival |
title_full_unstemmed | Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival |
title_short | Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival |
title_sort | effects of extra virgin olive oil polyphenols on beta-cell function and survival |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913337/ https://www.ncbi.nlm.nih.gov/pubmed/33546278 http://dx.doi.org/10.3390/plants10020286 |
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