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T-Cell Dysfunction as a Limitation of Adoptive Immunotherapy: Current Concepts and Mitigation Strategies

SIMPLE SUMMARY: T cells are immune cells that can be used to target infections or cancers. Adoptive T-cell immunotherapy leverages these properties and/or confers new features to T cells through ex vivo manipulations prior to their use in patients. However, as a “living drug,” the function of these...

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Detalles Bibliográficos
Autores principales: Janelle, Valérie, Delisle, Jean-Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913380/
https://www.ncbi.nlm.nih.gov/pubmed/33546277
http://dx.doi.org/10.3390/cancers13040598