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Distinct effect of body mass index by sex as a prognostic factor in localized renal cell carcinoma treated with nephrectomy ~ data from a multi-institutional study in Japan ~
BACKGROUND: We assessed the prognostic value of body mass index (BMI) in Asian patients with localized RCC who underwent nephrectomy. METHODS: A total of 665 patients who underwent nephrectomy for localized RCC were enrolled in the present study and divided into the two BMI groups: i.e., BMI < 25...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913463/ https://www.ncbi.nlm.nih.gov/pubmed/33639880 http://dx.doi.org/10.1186/s12885-021-07883-9 |
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author | Tsutsumi, Takeshi Komura, Kazumasa Hashimoto, Takeshi Muraoka, Ryu Satake, Naoya Matsunaga, Tomohisa Tsujino, Takuya Yoshikawa, Yuki Takai, Tomoaki Minami, Koichiro Taniguchi, Kohei Tanaka, Tomohito Uehara, Hirofumi Hirano, Hajime Nomi, Hayahito Ibuki, Naokazu Takahara, Kiyoshi Inamoto, Teruo Ohno, Yoshio Azuma, Haruhito |
author_facet | Tsutsumi, Takeshi Komura, Kazumasa Hashimoto, Takeshi Muraoka, Ryu Satake, Naoya Matsunaga, Tomohisa Tsujino, Takuya Yoshikawa, Yuki Takai, Tomoaki Minami, Koichiro Taniguchi, Kohei Tanaka, Tomohito Uehara, Hirofumi Hirano, Hajime Nomi, Hayahito Ibuki, Naokazu Takahara, Kiyoshi Inamoto, Teruo Ohno, Yoshio Azuma, Haruhito |
author_sort | Tsutsumi, Takeshi |
collection | PubMed |
description | BACKGROUND: We assessed the prognostic value of body mass index (BMI) in Asian patients with localized RCC who underwent nephrectomy. METHODS: A total of 665 patients who underwent nephrectomy for localized RCC were enrolled in the present study and divided into the two BMI groups: i.e., BMI < 25 in 463 (69.6%) and BMI > 25 in 202 (30.4%) patients. RESULTS: In total, there were 482 (72.5%) males and 183 (27.5%) females. Five-year cancer-specific survival (CSS) rates were significantly higher in increased BMI than the lower BMI group (97.1 and 92.5%: P = 0.007). When stratified by sex, significantly longer CSS in higher BMI was confirmed in males (5-year CSS of 92.7% in BMI < 25 and 98.1% in BMI > 25, p = 0.005), while there was no difference in CSS between BMI groups for female patients. Multivariable analysis exhibited that higher BMI was an independent predictor for favorable CSS in male (cox model: p = 0.041, Fine & Gray regression model: p = 0.014), but not in the female. Subgroup analysis for CSS revealed that favorable CSS with higher BMI was observed in patient subgroups of age < 65 (p = 0.019), clear cell histology (p = 0.018), and tumor size > 4 cm, p = 0.020) as well as male (p = 0.020). CONCLUSION: Our findings collected from the multi-institutional Japanese dataset demonstrated longer survival in patients with higher BMI than lower BMI for non-metastatic RCC treated with nephrectomy. Intriguingly, this finding was restricted to males, but not to females. |
format | Online Article Text |
id | pubmed-7913463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-79134632021-03-02 Distinct effect of body mass index by sex as a prognostic factor in localized renal cell carcinoma treated with nephrectomy ~ data from a multi-institutional study in Japan ~ Tsutsumi, Takeshi Komura, Kazumasa Hashimoto, Takeshi Muraoka, Ryu Satake, Naoya Matsunaga, Tomohisa Tsujino, Takuya Yoshikawa, Yuki Takai, Tomoaki Minami, Koichiro Taniguchi, Kohei Tanaka, Tomohito Uehara, Hirofumi Hirano, Hajime Nomi, Hayahito Ibuki, Naokazu Takahara, Kiyoshi Inamoto, Teruo Ohno, Yoshio Azuma, Haruhito BMC Cancer Research Article BACKGROUND: We assessed the prognostic value of body mass index (BMI) in Asian patients with localized RCC who underwent nephrectomy. METHODS: A total of 665 patients who underwent nephrectomy for localized RCC were enrolled in the present study and divided into the two BMI groups: i.e., BMI < 25 in 463 (69.6%) and BMI > 25 in 202 (30.4%) patients. RESULTS: In total, there were 482 (72.5%) males and 183 (27.5%) females. Five-year cancer-specific survival (CSS) rates were significantly higher in increased BMI than the lower BMI group (97.1 and 92.5%: P = 0.007). When stratified by sex, significantly longer CSS in higher BMI was confirmed in males (5-year CSS of 92.7% in BMI < 25 and 98.1% in BMI > 25, p = 0.005), while there was no difference in CSS between BMI groups for female patients. Multivariable analysis exhibited that higher BMI was an independent predictor for favorable CSS in male (cox model: p = 0.041, Fine & Gray regression model: p = 0.014), but not in the female. Subgroup analysis for CSS revealed that favorable CSS with higher BMI was observed in patient subgroups of age < 65 (p = 0.019), clear cell histology (p = 0.018), and tumor size > 4 cm, p = 0.020) as well as male (p = 0.020). CONCLUSION: Our findings collected from the multi-institutional Japanese dataset demonstrated longer survival in patients with higher BMI than lower BMI for non-metastatic RCC treated with nephrectomy. Intriguingly, this finding was restricted to males, but not to females. BioMed Central 2021-02-27 /pmc/articles/PMC7913463/ /pubmed/33639880 http://dx.doi.org/10.1186/s12885-021-07883-9 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Tsutsumi, Takeshi Komura, Kazumasa Hashimoto, Takeshi Muraoka, Ryu Satake, Naoya Matsunaga, Tomohisa Tsujino, Takuya Yoshikawa, Yuki Takai, Tomoaki Minami, Koichiro Taniguchi, Kohei Tanaka, Tomohito Uehara, Hirofumi Hirano, Hajime Nomi, Hayahito Ibuki, Naokazu Takahara, Kiyoshi Inamoto, Teruo Ohno, Yoshio Azuma, Haruhito Distinct effect of body mass index by sex as a prognostic factor in localized renal cell carcinoma treated with nephrectomy ~ data from a multi-institutional study in Japan ~ |
title | Distinct effect of body mass index by sex as a prognostic factor in localized renal cell carcinoma treated with nephrectomy ~ data from a multi-institutional study in Japan ~ |
title_full | Distinct effect of body mass index by sex as a prognostic factor in localized renal cell carcinoma treated with nephrectomy ~ data from a multi-institutional study in Japan ~ |
title_fullStr | Distinct effect of body mass index by sex as a prognostic factor in localized renal cell carcinoma treated with nephrectomy ~ data from a multi-institutional study in Japan ~ |
title_full_unstemmed | Distinct effect of body mass index by sex as a prognostic factor in localized renal cell carcinoma treated with nephrectomy ~ data from a multi-institutional study in Japan ~ |
title_short | Distinct effect of body mass index by sex as a prognostic factor in localized renal cell carcinoma treated with nephrectomy ~ data from a multi-institutional study in Japan ~ |
title_sort | distinct effect of body mass index by sex as a prognostic factor in localized renal cell carcinoma treated with nephrectomy ~ data from a multi-institutional study in japan ~ |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913463/ https://www.ncbi.nlm.nih.gov/pubmed/33639880 http://dx.doi.org/10.1186/s12885-021-07883-9 |
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