Cargando…

Bacteria and Host Interplay in Staphylococcus aureus Septic Arthritis and Sepsis

Staphylococcus aureus (S. aureus) infections are a major healthcare challenge and new treatment alternatives are needed. S. aureus septic arthritis, a debilitating joint disease, causes permanent joint dysfunction in almost 50% of the patients. S. aureus bacteremia is associated with higher mortalit...

Descripción completa

Detalles Bibliográficos
Autores principales: Jin, Tao, Mohammad, Majd, Pullerits, Rille, Ali, Abukar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913561/
https://www.ncbi.nlm.nih.gov/pubmed/33546401
http://dx.doi.org/10.3390/pathogens10020158
_version_ 1783656830149328896
author Jin, Tao
Mohammad, Majd
Pullerits, Rille
Ali, Abukar
author_facet Jin, Tao
Mohammad, Majd
Pullerits, Rille
Ali, Abukar
author_sort Jin, Tao
collection PubMed
description Staphylococcus aureus (S. aureus) infections are a major healthcare challenge and new treatment alternatives are needed. S. aureus septic arthritis, a debilitating joint disease, causes permanent joint dysfunction in almost 50% of the patients. S. aureus bacteremia is associated with higher mortalities than bacteremia caused by most other microbes and can develop to severe sepsis and death. The key to new therapies is understanding the interplay between bacterial virulence factors and host immune response, which decides the disease outcome. S. aureus produces numerous virulence factors that facilitate bacterial dissemination, invasion into joint cavity, and cause septic arthritis. Monocytes, activated by several components of S. aureus such as lipoproteins, are responsible for bone destructions. In S. aureus sepsis, cytokine storm induced by S. aureus components leads to the hyperinflammatory status, DIC, multiple organ failure, and later death. The immune suppressive therapies at the very early time point might be protective. However, the timing of treatment is crucial, as late treatment may aggravate the immune paralysis and lead to uncontrolled infection and death.
format Online
Article
Text
id pubmed-7913561
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79135612021-02-28 Bacteria and Host Interplay in Staphylococcus aureus Septic Arthritis and Sepsis Jin, Tao Mohammad, Majd Pullerits, Rille Ali, Abukar Pathogens Review Staphylococcus aureus (S. aureus) infections are a major healthcare challenge and new treatment alternatives are needed. S. aureus septic arthritis, a debilitating joint disease, causes permanent joint dysfunction in almost 50% of the patients. S. aureus bacteremia is associated with higher mortalities than bacteremia caused by most other microbes and can develop to severe sepsis and death. The key to new therapies is understanding the interplay between bacterial virulence factors and host immune response, which decides the disease outcome. S. aureus produces numerous virulence factors that facilitate bacterial dissemination, invasion into joint cavity, and cause septic arthritis. Monocytes, activated by several components of S. aureus such as lipoproteins, are responsible for bone destructions. In S. aureus sepsis, cytokine storm induced by S. aureus components leads to the hyperinflammatory status, DIC, multiple organ failure, and later death. The immune suppressive therapies at the very early time point might be protective. However, the timing of treatment is crucial, as late treatment may aggravate the immune paralysis and lead to uncontrolled infection and death. MDPI 2021-02-03 /pmc/articles/PMC7913561/ /pubmed/33546401 http://dx.doi.org/10.3390/pathogens10020158 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jin, Tao
Mohammad, Majd
Pullerits, Rille
Ali, Abukar
Bacteria and Host Interplay in Staphylococcus aureus Septic Arthritis and Sepsis
title Bacteria and Host Interplay in Staphylococcus aureus Septic Arthritis and Sepsis
title_full Bacteria and Host Interplay in Staphylococcus aureus Septic Arthritis and Sepsis
title_fullStr Bacteria and Host Interplay in Staphylococcus aureus Septic Arthritis and Sepsis
title_full_unstemmed Bacteria and Host Interplay in Staphylococcus aureus Septic Arthritis and Sepsis
title_short Bacteria and Host Interplay in Staphylococcus aureus Septic Arthritis and Sepsis
title_sort bacteria and host interplay in staphylococcus aureus septic arthritis and sepsis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913561/
https://www.ncbi.nlm.nih.gov/pubmed/33546401
http://dx.doi.org/10.3390/pathogens10020158
work_keys_str_mv AT jintao bacteriaandhostinterplayinstaphylococcusaureussepticarthritisandsepsis
AT mohammadmajd bacteriaandhostinterplayinstaphylococcusaureussepticarthritisandsepsis
AT pulleritsrille bacteriaandhostinterplayinstaphylococcusaureussepticarthritisandsepsis
AT aliabukar bacteriaandhostinterplayinstaphylococcusaureussepticarthritisandsepsis