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Mammalian Orthoreovirus (MRV) Is Widespread in Wild Ungulates of Northern Italy

Mammalian orthoreoviruses (MRVs) are emerging infectious agents that may affect wild animals. MRVs are usually associated with asymptomatic or mild respiratory and enteric infections. However, severe clinical manifestations have been occasionally reported in human and animal hosts. An insight into t...

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Autores principales: Arnaboldi, Sara, Righi, Francesco, Filipello, Virginia, Trogu, Tiziana, Lelli, Davide, Bianchi, Alessandro, Bonardi, Silvia, Pavoni, Enrico, Bertasi, Barbara, Lavazza, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913563/
https://www.ncbi.nlm.nih.gov/pubmed/33546342
http://dx.doi.org/10.3390/v13020238
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author Arnaboldi, Sara
Righi, Francesco
Filipello, Virginia
Trogu, Tiziana
Lelli, Davide
Bianchi, Alessandro
Bonardi, Silvia
Pavoni, Enrico
Bertasi, Barbara
Lavazza, Antonio
author_facet Arnaboldi, Sara
Righi, Francesco
Filipello, Virginia
Trogu, Tiziana
Lelli, Davide
Bianchi, Alessandro
Bonardi, Silvia
Pavoni, Enrico
Bertasi, Barbara
Lavazza, Antonio
author_sort Arnaboldi, Sara
collection PubMed
description Mammalian orthoreoviruses (MRVs) are emerging infectious agents that may affect wild animals. MRVs are usually associated with asymptomatic or mild respiratory and enteric infections. However, severe clinical manifestations have been occasionally reported in human and animal hosts. An insight into their circulation is essential to minimize the risk of diffusion to farmed animals and possibly to humans. The aim of this study was to investigate the presence of likely zoonotic MRVs in wild ungulates. Liver samples were collected from wild boar, red deer, roe deer, and chamois. Samples originated from two areas (Sondrio and Parma provinces) in Northern Italy with different environmental characteristics. MRV detection was carried out by PCR; confirmation by sequencing and typing for MRV type 3, which has been frequently associated with disease in pigs, were carried out for positive samples. MRV prevalence was as high as 45.3% in wild boars and 40.6% in red deer in the Sondrio area, with lower prevalence in the Parma area (15.4% in wild boars). Our findings shed light on MRV occurrence and distribution in some wild species and posed the issue of their possible role as reservoir.
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spelling pubmed-79135632021-02-28 Mammalian Orthoreovirus (MRV) Is Widespread in Wild Ungulates of Northern Italy Arnaboldi, Sara Righi, Francesco Filipello, Virginia Trogu, Tiziana Lelli, Davide Bianchi, Alessandro Bonardi, Silvia Pavoni, Enrico Bertasi, Barbara Lavazza, Antonio Viruses Article Mammalian orthoreoviruses (MRVs) are emerging infectious agents that may affect wild animals. MRVs are usually associated with asymptomatic or mild respiratory and enteric infections. However, severe clinical manifestations have been occasionally reported in human and animal hosts. An insight into their circulation is essential to minimize the risk of diffusion to farmed animals and possibly to humans. The aim of this study was to investigate the presence of likely zoonotic MRVs in wild ungulates. Liver samples were collected from wild boar, red deer, roe deer, and chamois. Samples originated from two areas (Sondrio and Parma provinces) in Northern Italy with different environmental characteristics. MRV detection was carried out by PCR; confirmation by sequencing and typing for MRV type 3, which has been frequently associated with disease in pigs, were carried out for positive samples. MRV prevalence was as high as 45.3% in wild boars and 40.6% in red deer in the Sondrio area, with lower prevalence in the Parma area (15.4% in wild boars). Our findings shed light on MRV occurrence and distribution in some wild species and posed the issue of their possible role as reservoir. MDPI 2021-02-03 /pmc/articles/PMC7913563/ /pubmed/33546342 http://dx.doi.org/10.3390/v13020238 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Arnaboldi, Sara
Righi, Francesco
Filipello, Virginia
Trogu, Tiziana
Lelli, Davide
Bianchi, Alessandro
Bonardi, Silvia
Pavoni, Enrico
Bertasi, Barbara
Lavazza, Antonio
Mammalian Orthoreovirus (MRV) Is Widespread in Wild Ungulates of Northern Italy
title Mammalian Orthoreovirus (MRV) Is Widespread in Wild Ungulates of Northern Italy
title_full Mammalian Orthoreovirus (MRV) Is Widespread in Wild Ungulates of Northern Italy
title_fullStr Mammalian Orthoreovirus (MRV) Is Widespread in Wild Ungulates of Northern Italy
title_full_unstemmed Mammalian Orthoreovirus (MRV) Is Widespread in Wild Ungulates of Northern Italy
title_short Mammalian Orthoreovirus (MRV) Is Widespread in Wild Ungulates of Northern Italy
title_sort mammalian orthoreovirus (mrv) is widespread in wild ungulates of northern italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913563/
https://www.ncbi.nlm.nih.gov/pubmed/33546342
http://dx.doi.org/10.3390/v13020238
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