Cargando…

PEG Linker Improves Antitumor Efficacy and Safety of Affibody-Based Drug Conjugates

Antibody drug conjugates (ADCs) have become an important modality of clinical cancer treatment. However, traditional ADCs have some limitations, such as reduced permeability in solid tumors due to the high molecular weight of monoclonal antibodies, difficulty in preparation and heterogeneity of prod...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Qiyu, Li, Wenjing, Xu, Keyuan, Xing, Yutong, Shi, Haobo, Jing, Zhe, Li, Shuang, Hong, Zhangyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913616/ https://www.ncbi.nlm.nih.gov/pubmed/33546481 http://dx.doi.org/10.3390/ijms22041540

Ejemplares similares

Tumor Site-Specific Cleavage Improves the Antitumor Efficacy of Antibody–Drug Conjugates
por: Xu, Keyuan, et al.
Publicado: (2023)

A Single-Domain Antibody-Based Anti-PSMA Recombinant Immunotoxin Exhibits Specificity and Efficacy for Prostate Cancer Therapy
por: Xing, Yutong, et al.
Publicado: (2021)

A Potent Micron Neoantigen Tumor Vaccine GP‐Neoantigen Induces Robust Antitumor Activity in Multiple Tumor Models
por: Jing, Zhe, et al.
Publicado: (2022)

Effect of Inter-Domain Linker Composition on Biodistribution of ABD-Fused Affibody-Drug Conjugates Targeting HER2
por: Xu, Tianqi, et al.
Publicado: (2022)

Effects of PEG-Linker Chain Length of Folate-Linked Liposomal Formulations on Targeting Ability and Antitumor Activity of Encapsulated Drug
por: Lim, Chaemin, et al.
Publicado: (2023)

Recent Advances on Affibody- and DARPin-Conjugated Nanomaterials in Cancer Therapy
por: Gabriele, Federica, et al.
Publicado: (2023)

Stabilization of Resveratrol in Blood Circulation by Conjugation to mPEG and mPEG-PLA Polymers: Investigation of Conjugate Linker and Polymer Composition on Stability, Metabolism, Antioxidant Activity and Pharmacokinetic Profile
por: Siddalingappa, Basavaraj, et al.
Publicado: (2015)

Enhancing Antitumor Efficacy of Nucleoside Analog 5-Fluorodeoxyuridine on HER2-Overexpressing Breast Cancer by Affibody-Engineered DNA Nanoparticle
por: Zhang, Chao, et al.
Publicado: (2020)

Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution
por: Ding, Haozhong, et al.
Publicado: (2021)

Self-Assembled Micelles Composed of Doxorubicin Conjugated Y-Shaped PEG-Poly(glutamic acid)(2) Copolymers via Hydrazone Linkers
por: Sui, Bowen, et al.
Publicado: (2014)

Antibody–drug conjugates: Recent advances in linker chemistry
por: Su, Zheng, et al.
Publicado: (2021)

Antibody-drug conjugates: recent advances in conjugation and linker chemistries
por: Tsuchikama, Kyoji, et al.
Publicado: (2016)

Affibody molecules as engineered protein drugs
por: Frejd, Fredrik Y, et al.
Publicado: (2017)

Sulfatase-cleavable linkers for antibody-drug conjugates
por: Bargh, Jonathan D., et al.
Publicado: (2020)

Peroxide-cleavable linkers for antibody–drug conjugates
por: Ashman, Nicola, et al.
Publicado: (2023)

Dually Reactive Long Recombinant Linkers for Bioconjugations as an Alternative to PEG
por: Kjeldsen, Thomas, et al.
Publicado: (2020)

Affibody-Binding Ligands
por: Barozzi, Annalisa, et al.
Publicado: (2020)

Multimerization Increases Tumor Enrichment of Peptide–Photosensitizer Conjugates
por: Zhao, Jisi, et al.
Publicado: (2019)

Self-Assembled Nanomicelles of Affibody-Drug Conjugate with Excellent Therapeutic Property to Cure Ovary and Breast Cancers
por: Xia, Xuelin, et al.
Publicado: (2021)

10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG(1000)-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy
por: Yang, Linjie, et al.
Publicado: (2017)

Synthesis, physicochemical characterization, toxicity and efficacy of a PEG conjugate and a hybrid PEG conjugate nanoparticle formulation of the antibiotic moxifloxacin
por: Tshweu, Lesego L., et al.
Publicado: (2020)

Pharmacokinetic properties and antitumor efficacy of the 5-fluorouracil loaded PEG-hydrogel
por: Yi, Hee, et al.
Publicado: (2010)

Linkers: An Assurance for Controlled Delivery of Antibody-Drug Conjugate
por: Sheyi, Rotimi, et al.
Publicado: (2022)

Lysosomal-Cleavable Peptide Linkers in Antibody–Drug Conjugates
por: Balamkundu, Seetharamsing, et al.
Publicado: (2023)

Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length
por: Augusto, Marcelo T., et al.
Publicado: (2017)

Annonaceous acetogenins nanosuspensions stabilized by PCL-PEG block polymer: significantly improved antitumor efficacy
por: Hong, Jingyi, et al.
Publicado: (2016)

Antibody-Drug Conjugate Using Ionized Cys-Linker-MMAE as the Potent Payload Shows Optimal Therapeutic Safety
por: Wang, Yanming, et al.
Publicado: (2020)

Prokaryotic expression of antibodies and affibodies
por: Fernández, Luis Angel
Publicado: (2004)

The use of radiocobalt as a label improves imaging of EGFR using DOTA-conjugated Affibody molecule
por: Garousi, Javad, et al.
Publicado: (2017)

The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy
por: Yin, Wen, et al.
Publicado: (2021)

Glutamic acid–valine–citrulline linkers ensure stability and efficacy of antibody–drug conjugates in mice
por: Anami, Yasuaki, et al.
Publicado: (2018)

Antitumor activity of a 5T4 targeting antibody drug conjugate with a novel payload derived from MMAF via C‐Lock linker
por: Shi, Baoying, et al.
Publicado: (2019)

Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody–DM1 Drug Conjugates
por: Ding, Haozhong, et al.
Publicado: (2019)

Synthesis of SERS-active core–satellite nanoparticles using heterobifunctional PEG linkers
por: San Juan, Angela Michelle T., et al.
Publicado: (2021)

Linkers Having a Crucial Role in Antibody–Drug Conjugates
por: Lu, Jun, et al.
Publicado: (2016)

Mithramycin-loaded mPEG-PLGA nanoparticles exert potent antitumor efficacy against pancreatic carcinoma
por: Liu, Xu-Jie, et al.
Publicado: (2017)

Affibody-DyLight Conjugates for In Vivo Assessment of HER2 Expression by Near-Infrared Optical Imaging
por: Zielinski, Rafal, et al.
Publicado: (2012)

Safety of PEGylated recombinant human full‐length coagulation factor VIII (BAX 855) in the overall context of PEG and PEG conjugates
por: Stidl, R., et al.
Publicado: (2015)

Development of Photoremovable Linkers as a Novel Strategy to Improve the Pharmacokinetics of Drug Conjugates and Their Potential Application in Antibody–Drug Conjugates for Cancer Therapy
por: Johan, Audrey Nathania, et al.
Publicado: (2022)

Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules
por: Rinne, Sara S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kuucm20at3h7nkll575sj09jh7