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Seroprevalence of Bovine Brucellosis in Selected Districts of Zambia

Brucellosis is an infectious zoonosis that has huge economic and public health implications globally. The disease is prevalent in humans, livestock and wildlife in Sub-Saharan Africa. A cross-sectional study was conducted between 6 May 2017 and 31 July 2020 during which 1712 sera from 175 cattle her...

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Autores principales: Mfune, Ruth Lindizyani, Mubanga, Melai, Silwamba, Isaac, Sagamiko, Frederick, Mudenda, Steward, Daka, Victor, Godfroid, Jacques, Hangombe, Bernard M., Muma, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913639/
https://www.ncbi.nlm.nih.gov/pubmed/33546514
http://dx.doi.org/10.3390/ijerph18041436
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author Mfune, Ruth Lindizyani
Mubanga, Melai
Silwamba, Isaac
Sagamiko, Frederick
Mudenda, Steward
Daka, Victor
Godfroid, Jacques
Hangombe, Bernard M.
Muma, John B.
author_facet Mfune, Ruth Lindizyani
Mubanga, Melai
Silwamba, Isaac
Sagamiko, Frederick
Mudenda, Steward
Daka, Victor
Godfroid, Jacques
Hangombe, Bernard M.
Muma, John B.
author_sort Mfune, Ruth Lindizyani
collection PubMed
description Brucellosis is an infectious zoonosis that has huge economic and public health implications globally. The disease is prevalent in humans, livestock and wildlife in Sub-Saharan Africa. A cross-sectional study was conducted between 6 May 2017 and 31 July 2020 during which 1712 sera from 175 cattle herds in five districts from Southern, Western and Eastern Provinces of Zambia were collected and screened against brucellosis. The Rose Bengal Test (RBT) and competitive Enzyme-linked Immuno Assay (c-ELISA) were used in serial testing for the detection of antibodies against Brucella species. A total of 127 animals from 37 herds tested positive, giving overall individual animal and herd-level seroprevalences of 7.53% (95% CI: 6.28–8.78%) and 21.14% (95% CI: 15.0–27.2%), respectively. Namwala district had the highest herd seroprevalence (33.9%, 95% CI: 21.6–46.1%), while Lundazi did not record any seropositivity. Comparably, Southern Province had the highest individual animal (8.97%, 95% CI: 7–11%) and herd-level (28.5%, 95% CI: 20.3–36.7%) seroprevalences, although this was not statistically significant. Within Southern Province, higher seropositivity was observed in Namwala district (OR: 8.55; CI: 2.66–27.44), among female animals (OR: 2.48; CI: 1.38–4.46) and in those aged 11 years and above (OR: 2.67; CI: 1.34–5.34) as well as in gravid cows (OR: 4.34; CI: 2.08–8.92). Seropositivity was also observed among some animals with hygromas (OR: 6.5; CI: 0.45–94.08) and those with a history of abortion (OR: 1.13; CI: 0.18–7.28) although the findings were not statistically significant. Brucella seroprevalence among traditional cattle in Zambia remains high. Control programs against bovine brucellosis must be introduced to reduce its impact on human health and animal production.
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spelling pubmed-79136392021-02-28 Seroprevalence of Bovine Brucellosis in Selected Districts of Zambia Mfune, Ruth Lindizyani Mubanga, Melai Silwamba, Isaac Sagamiko, Frederick Mudenda, Steward Daka, Victor Godfroid, Jacques Hangombe, Bernard M. Muma, John B. Int J Environ Res Public Health Article Brucellosis is an infectious zoonosis that has huge economic and public health implications globally. The disease is prevalent in humans, livestock and wildlife in Sub-Saharan Africa. A cross-sectional study was conducted between 6 May 2017 and 31 July 2020 during which 1712 sera from 175 cattle herds in five districts from Southern, Western and Eastern Provinces of Zambia were collected and screened against brucellosis. The Rose Bengal Test (RBT) and competitive Enzyme-linked Immuno Assay (c-ELISA) were used in serial testing for the detection of antibodies against Brucella species. A total of 127 animals from 37 herds tested positive, giving overall individual animal and herd-level seroprevalences of 7.53% (95% CI: 6.28–8.78%) and 21.14% (95% CI: 15.0–27.2%), respectively. Namwala district had the highest herd seroprevalence (33.9%, 95% CI: 21.6–46.1%), while Lundazi did not record any seropositivity. Comparably, Southern Province had the highest individual animal (8.97%, 95% CI: 7–11%) and herd-level (28.5%, 95% CI: 20.3–36.7%) seroprevalences, although this was not statistically significant. Within Southern Province, higher seropositivity was observed in Namwala district (OR: 8.55; CI: 2.66–27.44), among female animals (OR: 2.48; CI: 1.38–4.46) and in those aged 11 years and above (OR: 2.67; CI: 1.34–5.34) as well as in gravid cows (OR: 4.34; CI: 2.08–8.92). Seropositivity was also observed among some animals with hygromas (OR: 6.5; CI: 0.45–94.08) and those with a history of abortion (OR: 1.13; CI: 0.18–7.28) although the findings were not statistically significant. Brucella seroprevalence among traditional cattle in Zambia remains high. Control programs against bovine brucellosis must be introduced to reduce its impact on human health and animal production. MDPI 2021-02-03 2021-02 /pmc/articles/PMC7913639/ /pubmed/33546514 http://dx.doi.org/10.3390/ijerph18041436 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mfune, Ruth Lindizyani
Mubanga, Melai
Silwamba, Isaac
Sagamiko, Frederick
Mudenda, Steward
Daka, Victor
Godfroid, Jacques
Hangombe, Bernard M.
Muma, John B.
Seroprevalence of Bovine Brucellosis in Selected Districts of Zambia
title Seroprevalence of Bovine Brucellosis in Selected Districts of Zambia
title_full Seroprevalence of Bovine Brucellosis in Selected Districts of Zambia
title_fullStr Seroprevalence of Bovine Brucellosis in Selected Districts of Zambia
title_full_unstemmed Seroprevalence of Bovine Brucellosis in Selected Districts of Zambia
title_short Seroprevalence of Bovine Brucellosis in Selected Districts of Zambia
title_sort seroprevalence of bovine brucellosis in selected districts of zambia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913639/
https://www.ncbi.nlm.nih.gov/pubmed/33546514
http://dx.doi.org/10.3390/ijerph18041436
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