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DNA G-quadruplexes for native mass spectrometry in potassium: a database of validated structures in electrospray-compatible conditions

G-quadruplex DNA structures have become attractive drug targets, and native mass spectrometry can provide detailed characterization of drug binding stoichiometry and affinity, potentially at high throughput. However, the G-quadruplex DNA polymorphism poses problems for interpreting ligand screening...

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Detalles Bibliográficos
Autores principales:	Ghosh, Anirban, Largy, Eric, Gabelica, Valérie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913678/ https://www.ncbi.nlm.nih.gov/pubmed/33555347 http://dx.doi.org/10.1093/nar/gkab039

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