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Structure of a reaction intermediate mimic in t(6)A biosynthesis bound in the active site of the TsaBD heterodimer from Escherichia coli

The tRNA modification N6-threonylcarbamoyladenosine (t(6)A) is universally conserved in all organisms. In bacteria, the biosynthesis of t(6)A requires four proteins (TsaBCDE) that catalyze the formation of t(6)A via the unstable intermediate l-threonylcarbamoyl-adenylate (TC-AMP). While the formatio...

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Detalles Bibliográficos
Autores principales:	Kopina, Brett J, Missoury, Sophia, Collinet, Bruno, Fulton, Mark G, Cirio, Charles, van Tilbeurgh, Herman, Lauhon, Charles T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913687/ https://www.ncbi.nlm.nih.gov/pubmed/33524148 http://dx.doi.org/10.1093/nar/gkab026

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