Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs

We previously reported that human Rev1 (hRev1) bound to a parallel-stranded G-quadruplex (G4) from the c-MYC promoter with high affinity. We have extended those results to include other G4 motifs, finding that hRev1 exhibited stronger affinity for parallel-stranded G4 than either anti-parallel or hy...

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Detalles Bibliográficos
Autores principales: Ketkar, Amit, Smith, Lane, Johnson, Callie, Richey, Alyssa, Berry, Makayla, Hartman, Jessica H, Maddukuri, Leena, Reed, Megan R, Gunderson, Julie E C, Leung, Justin W C, Eoff, Robert L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913688/
https://www.ncbi.nlm.nih.gov/pubmed/33555350
http://dx.doi.org/10.1093/nar/gkab041

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