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Clinical Progress in Proton Radiotherapy: Biological Unknowns
SIMPLE SUMMARY: Proton radiation therapy is a more recent type of radiotherapy that uses proton beams instead of classical photon or X-rays beams. The clinical benefit of proton therapy is that it allows to treat tumors more precisely. As a result, proton radiotherapy induces less toxicity to health...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913745/ https://www.ncbi.nlm.nih.gov/pubmed/33546432 http://dx.doi.org/10.3390/cancers13040604 |
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author | Vanderwaeren, Laura Dok, Rüveyda Verstrepen, Kevin Nuyts, Sandra |
author_facet | Vanderwaeren, Laura Dok, Rüveyda Verstrepen, Kevin Nuyts, Sandra |
author_sort | Vanderwaeren, Laura |
collection | PubMed |
description | SIMPLE SUMMARY: Proton radiation therapy is a more recent type of radiotherapy that uses proton beams instead of classical photon or X-rays beams. The clinical benefit of proton therapy is that it allows to treat tumors more precisely. As a result, proton radiotherapy induces less toxicity to healthy tissue near the tumor site. Despite the experience in the clinical use of protons, the response of cells to proton radiation, the radiobiology, is less understood. In this review, we describe the current knowledge about proton radiobiology. ABSTRACT: Clinical use of proton radiation has massively increased over the past years. The main reason for this is the beneficial depth-dose distribution of protons that allows to reduce toxicity to normal tissues surrounding the tumor. Despite the experience in the clinical use of protons, the radiobiology after proton irradiation compared to photon irradiation remains to be completely elucidated. Proton radiation may lead to differential damages and activation of biological processes. Here, we will review the current knowledge of proton radiobiology in terms of induction of reactive oxygen species, hypoxia, DNA damage response, as well as cell death after proton irradiation and radioresistance. |
format | Online Article Text |
id | pubmed-7913745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79137452021-02-28 Clinical Progress in Proton Radiotherapy: Biological Unknowns Vanderwaeren, Laura Dok, Rüveyda Verstrepen, Kevin Nuyts, Sandra Cancers (Basel) Review SIMPLE SUMMARY: Proton radiation therapy is a more recent type of radiotherapy that uses proton beams instead of classical photon or X-rays beams. The clinical benefit of proton therapy is that it allows to treat tumors more precisely. As a result, proton radiotherapy induces less toxicity to healthy tissue near the tumor site. Despite the experience in the clinical use of protons, the response of cells to proton radiation, the radiobiology, is less understood. In this review, we describe the current knowledge about proton radiobiology. ABSTRACT: Clinical use of proton radiation has massively increased over the past years. The main reason for this is the beneficial depth-dose distribution of protons that allows to reduce toxicity to normal tissues surrounding the tumor. Despite the experience in the clinical use of protons, the radiobiology after proton irradiation compared to photon irradiation remains to be completely elucidated. Proton radiation may lead to differential damages and activation of biological processes. Here, we will review the current knowledge of proton radiobiology in terms of induction of reactive oxygen species, hypoxia, DNA damage response, as well as cell death after proton irradiation and radioresistance. MDPI 2021-02-03 /pmc/articles/PMC7913745/ /pubmed/33546432 http://dx.doi.org/10.3390/cancers13040604 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Vanderwaeren, Laura Dok, Rüveyda Verstrepen, Kevin Nuyts, Sandra Clinical Progress in Proton Radiotherapy: Biological Unknowns |
title | Clinical Progress in Proton Radiotherapy: Biological Unknowns |
title_full | Clinical Progress in Proton Radiotherapy: Biological Unknowns |
title_fullStr | Clinical Progress in Proton Radiotherapy: Biological Unknowns |
title_full_unstemmed | Clinical Progress in Proton Radiotherapy: Biological Unknowns |
title_short | Clinical Progress in Proton Radiotherapy: Biological Unknowns |
title_sort | clinical progress in proton radiotherapy: biological unknowns |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913745/ https://www.ncbi.nlm.nih.gov/pubmed/33546432 http://dx.doi.org/10.3390/cancers13040604 |
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