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Clinical Progress in Proton Radiotherapy: Biological Unknowns

SIMPLE SUMMARY: Proton radiation therapy is a more recent type of radiotherapy that uses proton beams instead of classical photon or X-rays beams. The clinical benefit of proton therapy is that it allows to treat tumors more precisely. As a result, proton radiotherapy induces less toxicity to health...

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Detalles Bibliográficos
Autores principales: Vanderwaeren, Laura, Dok, Rüveyda, Verstrepen, Kevin, Nuyts, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913745/
https://www.ncbi.nlm.nih.gov/pubmed/33546432
http://dx.doi.org/10.3390/cancers13040604
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author Vanderwaeren, Laura
Dok, Rüveyda
Verstrepen, Kevin
Nuyts, Sandra
author_facet Vanderwaeren, Laura
Dok, Rüveyda
Verstrepen, Kevin
Nuyts, Sandra
author_sort Vanderwaeren, Laura
collection PubMed
description SIMPLE SUMMARY: Proton radiation therapy is a more recent type of radiotherapy that uses proton beams instead of classical photon or X-rays beams. The clinical benefit of proton therapy is that it allows to treat tumors more precisely. As a result, proton radiotherapy induces less toxicity to healthy tissue near the tumor site. Despite the experience in the clinical use of protons, the response of cells to proton radiation, the radiobiology, is less understood. In this review, we describe the current knowledge about proton radiobiology. ABSTRACT: Clinical use of proton radiation has massively increased over the past years. The main reason for this is the beneficial depth-dose distribution of protons that allows to reduce toxicity to normal tissues surrounding the tumor. Despite the experience in the clinical use of protons, the radiobiology after proton irradiation compared to photon irradiation remains to be completely elucidated. Proton radiation may lead to differential damages and activation of biological processes. Here, we will review the current knowledge of proton radiobiology in terms of induction of reactive oxygen species, hypoxia, DNA damage response, as well as cell death after proton irradiation and radioresistance.
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spelling pubmed-79137452021-02-28 Clinical Progress in Proton Radiotherapy: Biological Unknowns Vanderwaeren, Laura Dok, Rüveyda Verstrepen, Kevin Nuyts, Sandra Cancers (Basel) Review SIMPLE SUMMARY: Proton radiation therapy is a more recent type of radiotherapy that uses proton beams instead of classical photon or X-rays beams. The clinical benefit of proton therapy is that it allows to treat tumors more precisely. As a result, proton radiotherapy induces less toxicity to healthy tissue near the tumor site. Despite the experience in the clinical use of protons, the response of cells to proton radiation, the radiobiology, is less understood. In this review, we describe the current knowledge about proton radiobiology. ABSTRACT: Clinical use of proton radiation has massively increased over the past years. The main reason for this is the beneficial depth-dose distribution of protons that allows to reduce toxicity to normal tissues surrounding the tumor. Despite the experience in the clinical use of protons, the radiobiology after proton irradiation compared to photon irradiation remains to be completely elucidated. Proton radiation may lead to differential damages and activation of biological processes. Here, we will review the current knowledge of proton radiobiology in terms of induction of reactive oxygen species, hypoxia, DNA damage response, as well as cell death after proton irradiation and radioresistance. MDPI 2021-02-03 /pmc/articles/PMC7913745/ /pubmed/33546432 http://dx.doi.org/10.3390/cancers13040604 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vanderwaeren, Laura
Dok, Rüveyda
Verstrepen, Kevin
Nuyts, Sandra
Clinical Progress in Proton Radiotherapy: Biological Unknowns
title Clinical Progress in Proton Radiotherapy: Biological Unknowns
title_full Clinical Progress in Proton Radiotherapy: Biological Unknowns
title_fullStr Clinical Progress in Proton Radiotherapy: Biological Unknowns
title_full_unstemmed Clinical Progress in Proton Radiotherapy: Biological Unknowns
title_short Clinical Progress in Proton Radiotherapy: Biological Unknowns
title_sort clinical progress in proton radiotherapy: biological unknowns
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913745/
https://www.ncbi.nlm.nih.gov/pubmed/33546432
http://dx.doi.org/10.3390/cancers13040604
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