Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

PARP-1 is a key early responder to DNA damage in eukaryotic cells. An allosteric mechanism links initial sensing of DNA single-strand breaks by PARP-1’s F1 and F2 domains via a process of further domain assembly to activation of the catalytic domain (CAT); synthesis and attachment of poly(ADP-ribose...

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Detalles Bibliográficos
Autores principales: Ogden, Tom E H, Yang, Ji-Chun, Schimpl, Marianne, Easton, Laura E, Underwood, Elizabeth, Rawlins, Philip B, McCauley, Michael M, Langelier, Marie-France, Pascal, John M, Embrey, Kevin J, Neuhaus, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913765/
https://www.ncbi.nlm.nih.gov/pubmed/33511412
http://dx.doi.org/10.1093/nar/gkab020

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