BACH1 recruits NANOG and histone H3 lysine 4 methyltransferase MLL/SET1 complexes to regulate enhancer–promoter activity and maintains pluripotency

Maintenance of stem-cell identity requires proper regulation of enhancer activity. Both transcription factors OCT4/SOX2/NANOG and histone methyltransferase complexes MLL/SET1 were shown to regulate enhancer activity, but how they are regulated in embryonic stem cells (ESCs) remains further studies....

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Detalles Bibliográficos
Autores principales: Niu, Cong, Wang, Siqing, Guo, Jieyu, Wei, Xiangxiang, Jia, Mengping, Chen, Zhaoxiong, Gong, Wenxuan, Qin, Yue, Wang, Xinhong, Zhi, Xiuling, Lu, Meng, Chen, Sifeng, Gu, Mingxia, Zhang, Jianyi, Han, Jing-Dong J, Lan, Fei, Meng, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913776/
https://www.ncbi.nlm.nih.gov/pubmed/33503260
http://dx.doi.org/10.1093/nar/gkab034

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