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Local Bone Mineral Density, Subcutaneous and Visceral Adipose Tissue Measurements in Routine Multi Detector Computed Tomography—Which Parameter Predicts Incident Vertebral Fractures Best?

In this case-control study the value of bone mineral density (BMD) at different vertebral levels, subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) to identify patients with incident osteoporotic vertebral fractures in routine multi-detector computed tomography (MDCT) exams was as...

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Autores principales: Burian, Egon, Grundl, Lioba, Greve, Tobias, Junker, Daniela, Sollmann, Nico, Löffler, Maximilian, Makowski, Marcus R., Zimmer, Claus, Kirschke, Jan S., Baum, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913817/
https://www.ncbi.nlm.nih.gov/pubmed/33557092
http://dx.doi.org/10.3390/diagnostics11020240
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author Burian, Egon
Grundl, Lioba
Greve, Tobias
Junker, Daniela
Sollmann, Nico
Löffler, Maximilian
Makowski, Marcus R.
Zimmer, Claus
Kirschke, Jan S.
Baum, Thomas
author_facet Burian, Egon
Grundl, Lioba
Greve, Tobias
Junker, Daniela
Sollmann, Nico
Löffler, Maximilian
Makowski, Marcus R.
Zimmer, Claus
Kirschke, Jan S.
Baum, Thomas
author_sort Burian, Egon
collection PubMed
description In this case-control study the value of bone mineral density (BMD) at different vertebral levels, subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) to identify patients with incident osteoporotic vertebral fractures in routine multi-detector computed tomography (MDCT) exams was assessed. Material and methods: Seventeen patients who underwent baseline and follow-up routine contrast-enhanced MDCT and had an incident osteoporotic vertebral fracture at follow-up were included. Seventeen age-, sex- and follow-up duration-matched controls were identified. Trabecular BMD (from Th5 to L5) as well as cross-sectional area of SAT and VAT were extracted. Results: BMD performed best to differentiate patients with an incident fracture from controls at the levels of Th5 (area under the curve [AUC] = 0.781, p = 0.014), Th7 (AUC = 0.877, p = 0.001), and Th9 (AUC = 0.818, p = 0.005). Applying multivariate logistic regression BMD at Th7 level remained the only significant predictor of incident vertebral fractures (Th5-L5) with an odds ratio of 1.07 per BMD SD decrease. VAT and SAT did not show significant differences between the fracture and control group (p > 0.05). Conclusion: The local BMD measurement appears to be more suitable than standard mean BMD from L1–L3 for fracture risk assessment.
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spelling pubmed-79138172021-02-28 Local Bone Mineral Density, Subcutaneous and Visceral Adipose Tissue Measurements in Routine Multi Detector Computed Tomography—Which Parameter Predicts Incident Vertebral Fractures Best? Burian, Egon Grundl, Lioba Greve, Tobias Junker, Daniela Sollmann, Nico Löffler, Maximilian Makowski, Marcus R. Zimmer, Claus Kirschke, Jan S. Baum, Thomas Diagnostics (Basel) Article In this case-control study the value of bone mineral density (BMD) at different vertebral levels, subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) to identify patients with incident osteoporotic vertebral fractures in routine multi-detector computed tomography (MDCT) exams was assessed. Material and methods: Seventeen patients who underwent baseline and follow-up routine contrast-enhanced MDCT and had an incident osteoporotic vertebral fracture at follow-up were included. Seventeen age-, sex- and follow-up duration-matched controls were identified. Trabecular BMD (from Th5 to L5) as well as cross-sectional area of SAT and VAT were extracted. Results: BMD performed best to differentiate patients with an incident fracture from controls at the levels of Th5 (area under the curve [AUC] = 0.781, p = 0.014), Th7 (AUC = 0.877, p = 0.001), and Th9 (AUC = 0.818, p = 0.005). Applying multivariate logistic regression BMD at Th7 level remained the only significant predictor of incident vertebral fractures (Th5-L5) with an odds ratio of 1.07 per BMD SD decrease. VAT and SAT did not show significant differences between the fracture and control group (p > 0.05). Conclusion: The local BMD measurement appears to be more suitable than standard mean BMD from L1–L3 for fracture risk assessment. MDPI 2021-02-04 /pmc/articles/PMC7913817/ /pubmed/33557092 http://dx.doi.org/10.3390/diagnostics11020240 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Burian, Egon
Grundl, Lioba
Greve, Tobias
Junker, Daniela
Sollmann, Nico
Löffler, Maximilian
Makowski, Marcus R.
Zimmer, Claus
Kirschke, Jan S.
Baum, Thomas
Local Bone Mineral Density, Subcutaneous and Visceral Adipose Tissue Measurements in Routine Multi Detector Computed Tomography—Which Parameter Predicts Incident Vertebral Fractures Best?
title Local Bone Mineral Density, Subcutaneous and Visceral Adipose Tissue Measurements in Routine Multi Detector Computed Tomography—Which Parameter Predicts Incident Vertebral Fractures Best?
title_full Local Bone Mineral Density, Subcutaneous and Visceral Adipose Tissue Measurements in Routine Multi Detector Computed Tomography—Which Parameter Predicts Incident Vertebral Fractures Best?
title_fullStr Local Bone Mineral Density, Subcutaneous and Visceral Adipose Tissue Measurements in Routine Multi Detector Computed Tomography—Which Parameter Predicts Incident Vertebral Fractures Best?
title_full_unstemmed Local Bone Mineral Density, Subcutaneous and Visceral Adipose Tissue Measurements in Routine Multi Detector Computed Tomography—Which Parameter Predicts Incident Vertebral Fractures Best?
title_short Local Bone Mineral Density, Subcutaneous and Visceral Adipose Tissue Measurements in Routine Multi Detector Computed Tomography—Which Parameter Predicts Incident Vertebral Fractures Best?
title_sort local bone mineral density, subcutaneous and visceral adipose tissue measurements in routine multi detector computed tomography—which parameter predicts incident vertebral fractures best?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913817/
https://www.ncbi.nlm.nih.gov/pubmed/33557092
http://dx.doi.org/10.3390/diagnostics11020240
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