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Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates

Total parenteral nutrition (TPN) is a life-saving intervention for infants that are unable to feed by mouth. Infants that remain on TPN for extended periods of time are at risk for the development of liver injury in the form of parenteral nutrition associated cholestasis (PNAC). Current research sug...

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Autores principales: Guthrie, Gregory, Burrin, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913904/
https://www.ncbi.nlm.nih.gov/pubmed/33557154
http://dx.doi.org/10.3390/nu13020508
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author Guthrie, Gregory
Burrin, Douglas
author_facet Guthrie, Gregory
Burrin, Douglas
author_sort Guthrie, Gregory
collection PubMed
description Total parenteral nutrition (TPN) is a life-saving intervention for infants that are unable to feed by mouth. Infants that remain on TPN for extended periods of time are at risk for the development of liver injury in the form of parenteral nutrition associated cholestasis (PNAC). Current research suggests the lipid component of TPN is a factor in the development of PNAC. Most notably, the fatty acid composition, vitamin E concentration, and presence of phytosterols are believed key mediators of lipid emulsion driven PNAC development. New emulsions comprised of fish oil and medium chain triglycerides show promise for reducing the incidence of PNAC in infants. In this review we will cover the current clinical studies on the benefit of fish oil and medium chain triglyceride containing lipid emulsions on the development of PNAC, the current constituents of lipid emulsions that may modulate the prevalence of PNAC, and potential new supplements to TPN to further reduce the incidence of PNAC.
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spelling pubmed-79139042021-02-28 Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates Guthrie, Gregory Burrin, Douglas Nutrients Review Total parenteral nutrition (TPN) is a life-saving intervention for infants that are unable to feed by mouth. Infants that remain on TPN for extended periods of time are at risk for the development of liver injury in the form of parenteral nutrition associated cholestasis (PNAC). Current research suggests the lipid component of TPN is a factor in the development of PNAC. Most notably, the fatty acid composition, vitamin E concentration, and presence of phytosterols are believed key mediators of lipid emulsion driven PNAC development. New emulsions comprised of fish oil and medium chain triglycerides show promise for reducing the incidence of PNAC in infants. In this review we will cover the current clinical studies on the benefit of fish oil and medium chain triglyceride containing lipid emulsions on the development of PNAC, the current constituents of lipid emulsions that may modulate the prevalence of PNAC, and potential new supplements to TPN to further reduce the incidence of PNAC. MDPI 2021-02-04 /pmc/articles/PMC7913904/ /pubmed/33557154 http://dx.doi.org/10.3390/nu13020508 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guthrie, Gregory
Burrin, Douglas
Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates
title Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates
title_full Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates
title_fullStr Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates
title_full_unstemmed Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates
title_short Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates
title_sort impact of parenteral lipid emulsion components on cholestatic liver disease in neonates
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913904/
https://www.ncbi.nlm.nih.gov/pubmed/33557154
http://dx.doi.org/10.3390/nu13020508
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