Leishmanicidal Activity of Betulin Derivatives in Leishmania amazonensis; Effect on Plasma and Mitochondrial Membrane Potential, and Macrophage Nitric Oxide and Superoxide Production

Herein, we evaluated in vitro the anti-leishmanial activity of betulin derivatives in Venezuelan isolates of Leishmania amazonensis, isolated from patients with therapeutic failure. Methods: We analyzed promastigote in vitro susceptibility as well as the cytotoxicity and selectivity of the evaluated...

Descripción completa

Detalles Bibliográficos
Autores principales: Alcazar, Wilmer, Alakurtti, Sami, Padrón-Nieves, Maritza, Tuononen, Maija Liisa, Rodríguez, Noris, Yli-Kauhaluoma, Jari, Ponte-Sucre, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913927/
https://www.ncbi.nlm.nih.gov/pubmed/33557150
http://dx.doi.org/10.3390/microorganisms9020320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913927/
https://www.ncbi.nlm.nih.gov/pubmed/33557150
http://dx.doi.org/10.3390/microorganisms9020320

Ejemplares similares