Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice

BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2 and broke out as a global pandemic in late 2019. The acidic pH environment of endosomes is believed to be essential for SARS-CoV-2 to be able to enter cells and begin replication. However, the clinical use of endosomal acidifica...

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Detalles Bibliográficos
Autores principales: Shang, Chao, Zhuang, Xinyu, Zhang, He, Li, Yiquan, Zhu, Yilong, Lu, Jing, Ge, Chenchen, Cong, Jianan, Li, Tingyu, Tian, Mingyao, Jin, Ningyi, Li, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914043/
https://www.ncbi.nlm.nih.gov/pubmed/33639976
http://dx.doi.org/10.1186/s12985-021-01515-1

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