Structure-activity relationship (SAR) and molecular dynamics study of withaferin-A fragment derivatives as potential therapeutic lead against main protease (M(pro)) of SARS-CoV-2

The spread of novel coronavirus SARS-CoV-2 has directed to a state of an unprecedented global pandemic. Many synthetic compounds and FDA-approved drugs have been significantly inhibitory against the virus, but no SARS-CoV-2 solution has been identified. However, small molecule fragment–based derivat...

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Detalles Bibliográficos
Autores principales: Ghosh, Arabinda, Chakraborty, Monoswi, Chandra, Anshuman, Alam, Mohamad Parvez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914120/
https://www.ncbi.nlm.nih.gov/pubmed/33641023
http://dx.doi.org/10.1007/s00894-021-04703-6

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