Inhibition of Bruton’s tyrosine kinase as a therapeutic strategy for chemoresistant oral squamous cell carcinoma and potential suppression of cancer stemness

Locally advanced oral squamous cell carcinoma (OSCC) requires multimodal therapy, including surgery and concurrent chemoradiotherapy (CCRT). CCRT-resistant and recurrent cancer has a poor prognosis. We investigated the effects of Bruton’s tyrosine kinase (BTK) on CCRT-resistant OSCC tissues. The eff...

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Detalles Bibliográficos
Autores principales: Liu, Shao-Cheng, Wu, Yang-Che, Huang, Chih-Ming, Hsieh, Ming-Shou, Huang, Ting-Yi, Huang, Chin-Sheng, Hsu, Tung-Nien, Huang, Mao-Suan, Lee, Wei-Hwa, Yeh, Chi-Tai, Lin, Chun-Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914253/
https://www.ncbi.nlm.nih.gov/pubmed/33640903
http://dx.doi.org/10.1038/s41389-021-00308-z

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