Impairment of type H vessels by NOX2-mediated endothelial oxidative stress: critical mechanisms and therapeutic targets for bone fragility in streptozotocin-induced type 1 diabetic mice

Rationale: Mechanisms underlying the compromised bone formation in type 1 diabetes mellitus (T1DM), which causes bone fragility and frequent fractures, remain poorly understood. Recent advances in organ-specific vascular endothelial cells (ECs) identify type H blood vessel injury in the bone, which...

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Detalles Bibliográficos
Autores principales: Hu, Xiao-Fan, Xiang, Geng, Wang, Tian-Ji, Ma, Yu-Bo, Zhang, Yang, Yan, Ya-Bo, Zhao, Xiong, Wu, Zi-Xiang, Feng, Ya-Fei, Lei, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914348/
https://www.ncbi.nlm.nih.gov/pubmed/33664862
http://dx.doi.org/10.7150/thno.50907

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