Cargando…

Vitamin C sensitizes triple negative breast cancer to PI3K inhibition therapy

Rationale: The clinical use of PI3K inhibitors, such as buparlisib, has been plagued with toxicity at effective doses. The aim of this study is to determine if vitamin C, a potent epigenetic regulator, can improve the therapeutic outcome and reduce the dose of buparlisib in treating PIK3CA-mutated t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mustafi, Sushmita, Camarena, Vladimir, Qureshi, Rehana, Sant, David W., Wilkes, Zachary, Bilbao, Daniel, Slingerland, Joyce, Kesmodel, Susan B., Wang, Gaofeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914363/ https://www.ncbi.nlm.nih.gov/pubmed/33664847 http://dx.doi.org/10.7150/thno.53225

Ejemplares similares

Vitamin C supplementation expands the therapeutic window of BETi for triple negative breast cancer
por: Mustafi, Sushmita, et al.
Publicado: (2019)

Vitamin C Inhibits Triple-Negative Breast Cancer Metastasis by Affecting the Expression of YAP1 and Synaptopodin 2
por: Gan, Liping, et al.
Publicado: (2019)

Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression
por: Sant, David W., et al.
Publicado: (2018)

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells
por: Sant, David W., et al.
Publicado: (2018)

Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expression
por: Mustafi, Sushmita, et al.
Publicado: (2017)

cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool
por: Camarena, Vladimir, et al.
Publicado: (2017)

Oscillatory cAMP signaling rapidly alters H3K4 methylation
por: Huff, Tyler C, et al.
Publicado: (2019)

Divergent effects of vitamins K1 and K2 on triple negative breast cancer cells
por: Beaudin, Sarah, et al.
Publicado: (2019)

Role of PTEN, PI3K, and mTOR in Triple-Negative Breast Cancer
por: Prvanović, Mirjana, et al.
Publicado: (2021)

Apatinib enhances the anti-tumor effect of paclitaxel via the PI3K/p65/Bcl-xl pathway in triple-negative breast cancer
por: Chen, Jing, et al.
Publicado: (2021)

MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade
por: Wang, Wei, et al.
Publicado: (2022)

Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K–AKT Pathway
por: Zhang, Daoyu, et al.
Publicado: (2020)

PI3K inhibition enhances the anti-tumor effect of eribulin in triple negative breast cancer
por: Rajput, Sandeep, et al.
Publicado: (2019)

Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling
por: Li, Hongchang, et al.
Publicado: (2021)

Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway
por: Massihnia, Daniela, et al.
Publicado: (2016)

Erianin induces triple-negative breast cancer cells apoptosis by activating PI3K/Akt pathway
por: Xu, Yonggang, et al.
Publicado: (2021)

Abrogating Metastatic Properties of Triple-Negative Breast Cancer Cells by EGFR and PI3K Dual Inhibitors
por: Garcia, Ana Rita, et al.
Publicado: (2023)

PI3K inhibition circumvents resistance to SHP2 blockade in metastatic triple-negative breast cancer
por: Amante, Romain J., et al.
Publicado: (2023)

GPRC5A Is a Negative Regulator of the Pro-Survival PI3K/Akt Signaling Pathway in Triple-Negative Breast Cancer
por: Yang, Lu, et al.
Publicado: (2021)

Dual PI3K and Wnt pathway inhibition is a synergistic combination against triple negative breast cancer
por: Solzak, Jeffrey P., et al.
Publicado: (2017)

Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer
por: Johnson, Jeremy, et al.
Publicado: (2020)

Proteomic Resistance Biomarkers for PI3K Inhibitor in Triple Negative Breast Cancer Patient-Derived Xenograft Models
por: Guo, Zhanfang, et al.
Publicado: (2020)

Treatment for Triple-Negative Breast Cancer: An Umbrella Review of Meta-Analyses
por: Yin, Jianyun, et al.
Publicado: (2022)

DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer
por: Kurani, Hetakshi, et al.
Publicado: (2022)

PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer
por: Guo, Fengzhu, et al.
Publicado: (2023)

The hedgehog pathway in triple‐negative breast cancer
por: Habib, Joyce G., et al.
Publicado: (2016)

Inhibition of the PI3K/AKT pathway potentiates cytotoxicity of EGFR kinase inhibitors in triple-negative breast cancer cells
por: Yi, Yong Weon, et al.
Publicado: (2013)

Androgens Induce Invasiveness of Triple Negative Breast Cancer Cells Through AR/Src/PI3-K Complex Assembly
por: Giovannelli, Pia, et al.
Publicado: (2019)

Novel therapeutic avenues in triple-negative breast cancer: PI3K/AKT inhibition, androgen receptor blockade, and beyond
por: Chan, Jack J., et al.
Publicado: (2019)

PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors
por: Lehmann, Brian D, et al.
Publicado: (2014)

Search for CP violation using triple product asymmetries in $\Lambda^{0}_{b}\to pK^{-}\pi^{+}\pi^{-}$, $\Lambda^{0}_{b}\to pK^{-}K^{+}K^{-}$ and $\Xi^{0}_{b}\to pK^{-}K^{-}\pi^{+}$ decays
por: Aaij, Roel, et al.
Publicado: (2018)

Strictinin, a novel ROR1-inhibitor, represses triple negative breast cancer survival and migration via modulation of PI3K/AKT/GSK3ß activity
por: Fultang, Norman, et al.
Publicado: (2019)

Opposite effects of the triple target (DNA-PK/PI3K/mTOR) inhibitor PI-103 on the radiation sensitivity of glioblastoma cell lines proficient and deficient in DNA-PKcs
por: Djuzenova, Cholpon S., et al.
Publicado: (2021)

Radiosensitization with combined use of olaparib and PI-103 in triple-negative breast cancer
por: Jang, Na Young, et al.
Publicado: (2015)

DEK promoted EMT and angiogenesis through regulating PI3K/AKT/mTOR pathway in triple-negative breast cancer
por: Yang, Yang, et al.
Publicado: (2017)

Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers
por: Tiwari, Aadhya, et al.
Publicado: (2020)

BCATc modulates crosstalk between the PI3K/Akt and the Ras/ERK pathway regulating proliferation in triple negative breast cancer
por: Shafei, Mai Ahmed, et al.
Publicado: (2020)

Sericin inhibits MDA-MB-468 cell proliferation via the PI3K/Akt pathway in triple-negative breast cancer
por: Niu, Lin, et al.
Publicado: (2021)

MAT as a promising therapeutic strategy against triple-negative breast cancer via inhibiting PI3K/AKT pathway
por: Wei, Shijie, et al.
Publicado: (2023)

Estrone, the major postmenopausal estrogen, binds ERa to induce SNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancer metastasis
por: Qureshi, Rehana, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_q11vvolgfl15dtg4i0aqujeqb9