Cargando…
Clostridium Difficile and COVID-19: Novel Risk Factors for Acute Portal Vein Thrombosis
The COVID-19 pandemic has created an unprecedented global health care crisis. COVID-19 patients are found to have increased thrombotic risk. Despite being on prophylactic anticoagulation, many develop serious arterial and venous thromboembolic events. Emerging reports indicate COVID-19 may be consid...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914382/ https://www.ncbi.nlm.nih.gov/pubmed/33728091 http://dx.doi.org/10.1155/2021/8832638 |
_version_ | 1783656989941825536 |
---|---|
author | Rokkam, Venkata Ram Pradeep Kutti Sridharan, Gurusaravanan Vegunta, Rathnamitreyee Vegunta, Radhakrishna Boregowda, Umesha Mohan, Babu P. |
author_facet | Rokkam, Venkata Ram Pradeep Kutti Sridharan, Gurusaravanan Vegunta, Rathnamitreyee Vegunta, Radhakrishna Boregowda, Umesha Mohan, Babu P. |
author_sort | Rokkam, Venkata Ram Pradeep |
collection | PubMed |
description | The COVID-19 pandemic has created an unprecedented global health care crisis. COVID-19 patients are found to have increased thrombotic risk. Despite being on prophylactic anticoagulation, many develop serious arterial and venous thromboembolic events. Emerging reports indicate COVID-19 may be considered a novel risk factor for portal vein thrombosis. Although, intra-abdominal infections are identified as risk factors, clostridium difficile colitis has not been typically seen as a risk factor for PVT. We report a case of an elderly female with a recent diagnosis of COVID-19 and no prior history of cirrhosis or malignancy who presented with diarrhea due to clostridium difficile infection. She developed sudden onset severe abdominal pain during the course of hospitalization. Acute portal vein thrombosis was identified on CT imaging of the abdomen, and she improved well with therapeutic anticoagulation. Acute portal vein thrombosis usually results from a combination of local and systemic prothrombotic risk factors. The combination of local infection by clostridium difficile and COVID-19 coagulopathy led to development of portal vein thrombosis in our patient. To the best of our knowledge, this is the first case of portal vein thrombosis reported in a patient with clostridium difficile infection in the setting of COVID-19 coagulopathy. During the current pandemic, clinicians should strongly consider abdominal imaging in patients presenting with abdominal pain due to clostridium difficile infection in the setting of COVID-19 to rule out complications such as portal vein thrombosis. Early diagnosis and treatment of portal vein thrombosis prevent complications of portal hypertension and intestinal infarctions. |
format | Online Article Text |
id | pubmed-7914382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-79143822021-03-15 Clostridium Difficile and COVID-19: Novel Risk Factors for Acute Portal Vein Thrombosis Rokkam, Venkata Ram Pradeep Kutti Sridharan, Gurusaravanan Vegunta, Rathnamitreyee Vegunta, Radhakrishna Boregowda, Umesha Mohan, Babu P. Case Rep Vasc Med Case Report The COVID-19 pandemic has created an unprecedented global health care crisis. COVID-19 patients are found to have increased thrombotic risk. Despite being on prophylactic anticoagulation, many develop serious arterial and venous thromboembolic events. Emerging reports indicate COVID-19 may be considered a novel risk factor for portal vein thrombosis. Although, intra-abdominal infections are identified as risk factors, clostridium difficile colitis has not been typically seen as a risk factor for PVT. We report a case of an elderly female with a recent diagnosis of COVID-19 and no prior history of cirrhosis or malignancy who presented with diarrhea due to clostridium difficile infection. She developed sudden onset severe abdominal pain during the course of hospitalization. Acute portal vein thrombosis was identified on CT imaging of the abdomen, and she improved well with therapeutic anticoagulation. Acute portal vein thrombosis usually results from a combination of local and systemic prothrombotic risk factors. The combination of local infection by clostridium difficile and COVID-19 coagulopathy led to development of portal vein thrombosis in our patient. To the best of our knowledge, this is the first case of portal vein thrombosis reported in a patient with clostridium difficile infection in the setting of COVID-19 coagulopathy. During the current pandemic, clinicians should strongly consider abdominal imaging in patients presenting with abdominal pain due to clostridium difficile infection in the setting of COVID-19 to rule out complications such as portal vein thrombosis. Early diagnosis and treatment of portal vein thrombosis prevent complications of portal hypertension and intestinal infarctions. Hindawi 2021-02-27 /pmc/articles/PMC7914382/ /pubmed/33728091 http://dx.doi.org/10.1155/2021/8832638 Text en Copyright © 2021 Venkata Ram Pradeep Rokkam et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Rokkam, Venkata Ram Pradeep Kutti Sridharan, Gurusaravanan Vegunta, Rathnamitreyee Vegunta, Radhakrishna Boregowda, Umesha Mohan, Babu P. Clostridium Difficile and COVID-19: Novel Risk Factors for Acute Portal Vein Thrombosis |
title | Clostridium Difficile and COVID-19: Novel Risk Factors for Acute Portal Vein Thrombosis |
title_full | Clostridium Difficile and COVID-19: Novel Risk Factors for Acute Portal Vein Thrombosis |
title_fullStr | Clostridium Difficile and COVID-19: Novel Risk Factors for Acute Portal Vein Thrombosis |
title_full_unstemmed | Clostridium Difficile and COVID-19: Novel Risk Factors for Acute Portal Vein Thrombosis |
title_short | Clostridium Difficile and COVID-19: Novel Risk Factors for Acute Portal Vein Thrombosis |
title_sort | clostridium difficile and covid-19: novel risk factors for acute portal vein thrombosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914382/ https://www.ncbi.nlm.nih.gov/pubmed/33728091 http://dx.doi.org/10.1155/2021/8832638 |
work_keys_str_mv | AT rokkamvenkatarampradeep clostridiumdifficileandcovid19novelriskfactorsforacuteportalveinthrombosis AT kuttisridharangurusaravanan clostridiumdifficileandcovid19novelriskfactorsforacuteportalveinthrombosis AT veguntarathnamitreyee clostridiumdifficileandcovid19novelriskfactorsforacuteportalveinthrombosis AT veguntaradhakrishna clostridiumdifficileandcovid19novelriskfactorsforacuteportalveinthrombosis AT boregowdaumesha clostridiumdifficileandcovid19novelriskfactorsforacuteportalveinthrombosis AT mohanbabup clostridiumdifficileandcovid19novelriskfactorsforacuteportalveinthrombosis |