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Oligodendroglial Heterogeneity in Neuropsychiatric Disease

Oligodendroglia interact with neurons to support their health and maintain the normal functioning of the central nervous system (CNS). Human oligodendroglia are a highly heterogeneous population characterised by distinct developmental origins and regional differences, as well as variation in cellula...

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Detalles Bibliográficos
Autores principales: Bøstrand, Sunniva M. K., Williams, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914430/
https://www.ncbi.nlm.nih.gov/pubmed/33562031
http://dx.doi.org/10.3390/life11020125
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author Bøstrand, Sunniva M. K.
Williams, Anna
author_facet Bøstrand, Sunniva M. K.
Williams, Anna
author_sort Bøstrand, Sunniva M. K.
collection PubMed
description Oligodendroglia interact with neurons to support their health and maintain the normal functioning of the central nervous system (CNS). Human oligodendroglia are a highly heterogeneous population characterised by distinct developmental origins and regional differences, as well as variation in cellular states, as evidenced by recent analysis at single-nuclei resolution. Increasingly, there is evidence to suggest that the highly heterogeneous nature of oligodendroglia might underpin their role in a range of CNS disorders, including those with neuropsychiatric symptoms. Understanding the role of oligodendroglial heterogeneity in this group of disorders might pave the way for novel approaches to identify biomarkers and develop treatments.
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spelling pubmed-79144302021-03-01 Oligodendroglial Heterogeneity in Neuropsychiatric Disease Bøstrand, Sunniva M. K. Williams, Anna Life (Basel) Review Oligodendroglia interact with neurons to support their health and maintain the normal functioning of the central nervous system (CNS). Human oligodendroglia are a highly heterogeneous population characterised by distinct developmental origins and regional differences, as well as variation in cellular states, as evidenced by recent analysis at single-nuclei resolution. Increasingly, there is evidence to suggest that the highly heterogeneous nature of oligodendroglia might underpin their role in a range of CNS disorders, including those with neuropsychiatric symptoms. Understanding the role of oligodendroglial heterogeneity in this group of disorders might pave the way for novel approaches to identify biomarkers and develop treatments. MDPI 2021-02-06 /pmc/articles/PMC7914430/ /pubmed/33562031 http://dx.doi.org/10.3390/life11020125 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bøstrand, Sunniva M. K.
Williams, Anna
Oligodendroglial Heterogeneity in Neuropsychiatric Disease
title Oligodendroglial Heterogeneity in Neuropsychiatric Disease
title_full Oligodendroglial Heterogeneity in Neuropsychiatric Disease
title_fullStr Oligodendroglial Heterogeneity in Neuropsychiatric Disease
title_full_unstemmed Oligodendroglial Heterogeneity in Neuropsychiatric Disease
title_short Oligodendroglial Heterogeneity in Neuropsychiatric Disease
title_sort oligodendroglial heterogeneity in neuropsychiatric disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914430/
https://www.ncbi.nlm.nih.gov/pubmed/33562031
http://dx.doi.org/10.3390/life11020125
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