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Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up

Background and Objectives: This was a retrospective single-center study to analyze and describe the clinical and histological features of all cases of oral solitary fibrous tumor (SFT). Study design: the study included all consecutive cases of oral SFT diagnosed between 2008–2018 at a single tertiar...

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Autores principales: Shmuly, Tom, Ben Zvi, Yehonatan, Chaushu, Gabriel, Kaplan, Ilana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914433/
https://www.ncbi.nlm.nih.gov/pubmed/33567630
http://dx.doi.org/10.3390/medicina57020152
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author Shmuly, Tom
Ben Zvi, Yehonatan
Chaushu, Gabriel
Kaplan, Ilana
author_facet Shmuly, Tom
Ben Zvi, Yehonatan
Chaushu, Gabriel
Kaplan, Ilana
author_sort Shmuly, Tom
collection PubMed
description Background and Objectives: This was a retrospective single-center study to analyze and describe the clinical and histological features of all cases of oral solitary fibrous tumor (SFT). Study design: the study included all consecutive cases of oral SFT diagnosed between 2008–2018 at a single tertiary center. Materials and Methods: Clinical data was retrieved from medical charts. The diagnosis of oral SFT was based upon the morphologic features of the lesions, in routine hematoxylin and eosin (H&E) stained sections and confirmed by immunohistochemical analyses including CD34, CD99, Bcl2, and stains for STAT6. Results: Seven cases of oral SFT were found. Of these, three (42%) were in males and four (58%) in females. The age range was 24–63 years (mean 47 ± 13). Four (58%) lesions were located in the buccal mucosa, two (28%) in the labial mucosa and one (14%) on the floor of the mouth. The diameter ranged between 3–50 mm (mean 22 ± 14 mm). All patients were treated with local excision. Follow-up periods were between 2–74 months (mean 41 ± 27). No recurrences were reported. Conclusions: We present a series of oral SFT, which were all non-aggressive in presentation and did not recur after conservative surgery (local excision) over a relatively long follow-up period.
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spelling pubmed-79144332021-03-01 Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up Shmuly, Tom Ben Zvi, Yehonatan Chaushu, Gabriel Kaplan, Ilana Medicina (Kaunas) Article Background and Objectives: This was a retrospective single-center study to analyze and describe the clinical and histological features of all cases of oral solitary fibrous tumor (SFT). Study design: the study included all consecutive cases of oral SFT diagnosed between 2008–2018 at a single tertiary center. Materials and Methods: Clinical data was retrieved from medical charts. The diagnosis of oral SFT was based upon the morphologic features of the lesions, in routine hematoxylin and eosin (H&E) stained sections and confirmed by immunohistochemical analyses including CD34, CD99, Bcl2, and stains for STAT6. Results: Seven cases of oral SFT were found. Of these, three (42%) were in males and four (58%) in females. The age range was 24–63 years (mean 47 ± 13). Four (58%) lesions were located in the buccal mucosa, two (28%) in the labial mucosa and one (14%) on the floor of the mouth. The diameter ranged between 3–50 mm (mean 22 ± 14 mm). All patients were treated with local excision. Follow-up periods were between 2–74 months (mean 41 ± 27). No recurrences were reported. Conclusions: We present a series of oral SFT, which were all non-aggressive in presentation and did not recur after conservative surgery (local excision) over a relatively long follow-up period. MDPI 2021-02-08 /pmc/articles/PMC7914433/ /pubmed/33567630 http://dx.doi.org/10.3390/medicina57020152 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shmuly, Tom
Ben Zvi, Yehonatan
Chaushu, Gabriel
Kaplan, Ilana
Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up
title Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up
title_full Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up
title_fullStr Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up
title_full_unstemmed Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up
title_short Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up
title_sort oral solitary fibrous tumor: a retrospective clinico-pathological study and long-term follow-up
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914433/
https://www.ncbi.nlm.nih.gov/pubmed/33567630
http://dx.doi.org/10.3390/medicina57020152
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