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Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy
We performed biological safety evaluation tests of three Ti–Zr alloys under accelerated extraction condition. We also conducted histopathological analysis of long-term implantation of pure V, Al, Ni, Zr, Nb, and Ta metals as well as Ni–Ti and high-V-containing Ti–15V–3Al–3Sn alloys in rats. The effe...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914436/ https://www.ncbi.nlm.nih.gov/pubmed/33557312 http://dx.doi.org/10.3390/ma14040731 |
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author | Okazaki, Yoshimitsu Katsuda, Shin-ichi |
author_facet | Okazaki, Yoshimitsu Katsuda, Shin-ichi |
author_sort | Okazaki, Yoshimitsu |
collection | PubMed |
description | We performed biological safety evaluation tests of three Ti–Zr alloys under accelerated extraction condition. We also conducted histopathological analysis of long-term implantation of pure V, Al, Ni, Zr, Nb, and Ta metals as well as Ni–Ti and high-V-containing Ti–15V–3Al–3Sn alloys in rats. The effect of the dental implant (screw) shape on morphometrical parameters was investigated using rabbits. Moreover, we examined the maximum pullout properties of grit-blasted Ti–Zr alloys after their implantation in rabbits. The biological safety evaluation tests of three Ti–Zr alloys (Ti–15Zr–4Nb, Ti–15Zr–4Nb–1Ta, and Ti–15Zr–4Nb–4Ta) showed no adverse (negative) effects of either normal or accelerated extraction. No bone was formed around the pure V and Ni implants. The Al, Zr, Nb, and Ni–Ti implants were surrounded by new bone. The new bone formed around Ti–Ni and high-V-containing Ti alloys tended to be thinner than that formed around Ti–Zr and Ti–6Al–4V alloys. The rate of bone formation on the threaded portion in the Ti–15Zr–4Nb–4Ta dental implant was the same as that on a smooth surface. The maximum pullout loads of the grit- and shot-blasted Ti–Zr alloys increased linearly with implantation period in rabbits. The pullout load of grit-blasted Ti–Zr alloy rods was higher than that of shot-blasted ones. The surface roughness (Ra) and area ratio of residual Al(2)O(3) particles of the Ti–15Zr–4Nb alloy surface grit-blasted with Al(2)O(3) particles were the same as those of the grit-blasted Alloclassic stem surface. It was clarified that the grit-blasted Ti–15Zr–4Nb alloy could be used for artificial hip joint stems. |
format | Online Article Text |
id | pubmed-7914436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79144362021-03-01 Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy Okazaki, Yoshimitsu Katsuda, Shin-ichi Materials (Basel) Article We performed biological safety evaluation tests of three Ti–Zr alloys under accelerated extraction condition. We also conducted histopathological analysis of long-term implantation of pure V, Al, Ni, Zr, Nb, and Ta metals as well as Ni–Ti and high-V-containing Ti–15V–3Al–3Sn alloys in rats. The effect of the dental implant (screw) shape on morphometrical parameters was investigated using rabbits. Moreover, we examined the maximum pullout properties of grit-blasted Ti–Zr alloys after their implantation in rabbits. The biological safety evaluation tests of three Ti–Zr alloys (Ti–15Zr–4Nb, Ti–15Zr–4Nb–1Ta, and Ti–15Zr–4Nb–4Ta) showed no adverse (negative) effects of either normal or accelerated extraction. No bone was formed around the pure V and Ni implants. The Al, Zr, Nb, and Ni–Ti implants were surrounded by new bone. The new bone formed around Ti–Ni and high-V-containing Ti alloys tended to be thinner than that formed around Ti–Zr and Ti–6Al–4V alloys. The rate of bone formation on the threaded portion in the Ti–15Zr–4Nb–4Ta dental implant was the same as that on a smooth surface. The maximum pullout loads of the grit- and shot-blasted Ti–Zr alloys increased linearly with implantation period in rabbits. The pullout load of grit-blasted Ti–Zr alloy rods was higher than that of shot-blasted ones. The surface roughness (Ra) and area ratio of residual Al(2)O(3) particles of the Ti–15Zr–4Nb alloy surface grit-blasted with Al(2)O(3) particles were the same as those of the grit-blasted Alloclassic stem surface. It was clarified that the grit-blasted Ti–15Zr–4Nb alloy could be used for artificial hip joint stems. MDPI 2021-02-04 /pmc/articles/PMC7914436/ /pubmed/33557312 http://dx.doi.org/10.3390/ma14040731 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Okazaki, Yoshimitsu Katsuda, Shin-ichi Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy |
title | Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy |
title_full | Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy |
title_fullStr | Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy |
title_full_unstemmed | Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy |
title_short | Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy |
title_sort | biological safety evaluation and surface modification of biocompatible ti–15zr–4nb alloy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914436/ https://www.ncbi.nlm.nih.gov/pubmed/33557312 http://dx.doi.org/10.3390/ma14040731 |
work_keys_str_mv | AT okazakiyoshimitsu biologicalsafetyevaluationandsurfacemodificationofbiocompatibleti15zr4nballoy AT katsudashinichi biologicalsafetyevaluationandsurfacemodificationofbiocompatibleti15zr4nballoy |