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Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection
Background: Zinc is an essential micronutrient that impacts host–pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseas...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914437/ https://www.ncbi.nlm.nih.gov/pubmed/33572045 http://dx.doi.org/10.3390/nu13020562 |
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author | Vogel-González, Marina Talló-Parra, Marc Herrera-Fernández, Víctor Pérez-Vilaró, Gemma Chillón, Miguel Nogués, Xavier Gómez-Zorrilla, Silvia López-Montesinos, Inmaculada Arnau-Barrés, Isabel Sorli-Redó, Maria Luisa Horcajada, Juan Pablo García-Giralt, Natalia Pascual, Julio Díez, Juana Vicente, Rubén Güerri-Fernández, Robert |
author_facet | Vogel-González, Marina Talló-Parra, Marc Herrera-Fernández, Víctor Pérez-Vilaró, Gemma Chillón, Miguel Nogués, Xavier Gómez-Zorrilla, Silvia López-Montesinos, Inmaculada Arnau-Barrés, Isabel Sorli-Redó, Maria Luisa Horcajada, Juan Pablo García-Giralt, Natalia Pascual, Julio Díez, Juana Vicente, Rubén Güerri-Fernández, Robert |
author_sort | Vogel-González, Marina |
collection | PubMed |
description | Background: Zinc is an essential micronutrient that impacts host–pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with an increased risk for severe severe coronavirus disease 2019 (COVID-19) outcomes. We hypothesize that serum zinc content (SZC) influences COVID-19 disease progression, and thus might represent a useful biomarker. Methods: We ran an observational cohort study with 249 COVID-19 patients admitted in Hospital del Mar. We have studied COVID-19 severity and progression attending to SZC at admission. In parallel, we have studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) replication in the Vero E6 cell line modifying zinc concentrations. Findings: Our study demonstrates a correlation between serum zinc levels and COVID-19 outcome. Serum zinc levels lower than 50 µg/dL at admission correlated with worse clinical presentation, longer time to reach stability, and higher mortality. Our in vitro results indicate that low zinc levels favor viral expansion in SARS-CoV-2 infected cells. Interpretation: Low SZC is a risk factor that determines COVID-19 outcome. We encourage performing randomized clinical trials to study zinc supplementation as potential prophylaxis and treatment with people at risk of zinc deficiency. |
format | Online Article Text |
id | pubmed-7914437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79144372021-03-01 Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection Vogel-González, Marina Talló-Parra, Marc Herrera-Fernández, Víctor Pérez-Vilaró, Gemma Chillón, Miguel Nogués, Xavier Gómez-Zorrilla, Silvia López-Montesinos, Inmaculada Arnau-Barrés, Isabel Sorli-Redó, Maria Luisa Horcajada, Juan Pablo García-Giralt, Natalia Pascual, Julio Díez, Juana Vicente, Rubén Güerri-Fernández, Robert Nutrients Article Background: Zinc is an essential micronutrient that impacts host–pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with an increased risk for severe severe coronavirus disease 2019 (COVID-19) outcomes. We hypothesize that serum zinc content (SZC) influences COVID-19 disease progression, and thus might represent a useful biomarker. Methods: We ran an observational cohort study with 249 COVID-19 patients admitted in Hospital del Mar. We have studied COVID-19 severity and progression attending to SZC at admission. In parallel, we have studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) replication in the Vero E6 cell line modifying zinc concentrations. Findings: Our study demonstrates a correlation between serum zinc levels and COVID-19 outcome. Serum zinc levels lower than 50 µg/dL at admission correlated with worse clinical presentation, longer time to reach stability, and higher mortality. Our in vitro results indicate that low zinc levels favor viral expansion in SARS-CoV-2 infected cells. Interpretation: Low SZC is a risk factor that determines COVID-19 outcome. We encourage performing randomized clinical trials to study zinc supplementation as potential prophylaxis and treatment with people at risk of zinc deficiency. MDPI 2021-02-09 /pmc/articles/PMC7914437/ /pubmed/33572045 http://dx.doi.org/10.3390/nu13020562 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vogel-González, Marina Talló-Parra, Marc Herrera-Fernández, Víctor Pérez-Vilaró, Gemma Chillón, Miguel Nogués, Xavier Gómez-Zorrilla, Silvia López-Montesinos, Inmaculada Arnau-Barrés, Isabel Sorli-Redó, Maria Luisa Horcajada, Juan Pablo García-Giralt, Natalia Pascual, Julio Díez, Juana Vicente, Rubén Güerri-Fernández, Robert Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection |
title | Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection |
title_full | Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection |
title_fullStr | Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection |
title_full_unstemmed | Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection |
title_short | Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection |
title_sort | low zinc levels at admission associates with poor clinical outcomes in sars-cov-2 infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914437/ https://www.ncbi.nlm.nih.gov/pubmed/33572045 http://dx.doi.org/10.3390/nu13020562 |
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