Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases

The discovery of the Estrogen Receptor Beta (ERβ) in 1996 opened new perspectives in the diagnostics and therapy of different types of cancer. Here, we present a review of the present research knowledge about its role in endocrine-related cancers: breast, prostate, and thyroid, and colorectal cancer...

Descripción completa

Detalles Bibliográficos
Autores principales: Božović, Ana, Mandušić, Vesna, Todorović, Lidija, Krajnović, Milena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914503/
https://www.ncbi.nlm.nih.gov/pubmed/33562134
http://dx.doi.org/10.3390/ijms22041656
_version_ 1783657017861210112
author Božović, Ana
Mandušić, Vesna
Todorović, Lidija
Krajnović, Milena
author_facet Božović, Ana
Mandušić, Vesna
Todorović, Lidija
Krajnović, Milena
author_sort Božović, Ana
collection PubMed
description The discovery of the Estrogen Receptor Beta (ERβ) in 1996 opened new perspectives in the diagnostics and therapy of different types of cancer. Here, we present a review of the present research knowledge about its role in endocrine-related cancers: breast, prostate, and thyroid, and colorectal cancers. We also discuss the reasons for the controversy of its role in carcinogenesis and why it is still not in use as a biomarker in clinical practice. Given that the diagnostics and therapy would benefit from the introduction of new biomarkers, we suggest ways to overcome the contradictions in elucidating the role of ERβ.
format Online
Article
Text
id pubmed-7914503
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79145032021-03-01 Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases Božović, Ana Mandušić, Vesna Todorović, Lidija Krajnović, Milena Int J Mol Sci Review The discovery of the Estrogen Receptor Beta (ERβ) in 1996 opened new perspectives in the diagnostics and therapy of different types of cancer. Here, we present a review of the present research knowledge about its role in endocrine-related cancers: breast, prostate, and thyroid, and colorectal cancers. We also discuss the reasons for the controversy of its role in carcinogenesis and why it is still not in use as a biomarker in clinical practice. Given that the diagnostics and therapy would benefit from the introduction of new biomarkers, we suggest ways to overcome the contradictions in elucidating the role of ERβ. MDPI 2021-02-06 /pmc/articles/PMC7914503/ /pubmed/33562134 http://dx.doi.org/10.3390/ijms22041656 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Božović, Ana
Mandušić, Vesna
Todorović, Lidija
Krajnović, Milena
Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases
title Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases
title_full Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases
title_fullStr Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases
title_full_unstemmed Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases
title_short Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases
title_sort estrogen receptor beta: the promising biomarker and potential target in metastases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914503/
https://www.ncbi.nlm.nih.gov/pubmed/33562134
http://dx.doi.org/10.3390/ijms22041656
work_keys_str_mv AT bozovicana estrogenreceptorbetathepromisingbiomarkerandpotentialtargetinmetastases
AT mandusicvesna estrogenreceptorbetathepromisingbiomarkerandpotentialtargetinmetastases
AT todoroviclidija estrogenreceptorbetathepromisingbiomarkerandpotentialtargetinmetastases
AT krajnovicmilena estrogenreceptorbetathepromisingbiomarkerandpotentialtargetinmetastases

Ejemplares similares