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Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?

The cardiovascular system can be programmed by a diversity of early-life insults, leading to cardiovascular disease (CVD) in adulthood. This notion is now termed developmental origins of health and disease (DOHaD). Emerging evidence indicates hydrogen sulfide (H(2)S), a crucial regulator of cardiova...

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Autores principales: Hsu, Chien-Ning, Tain, You-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914659/
https://www.ncbi.nlm.nih.gov/pubmed/33562763
http://dx.doi.org/10.3390/antiox10020247
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author Hsu, Chien-Ning
Tain, You-Lin
author_facet Hsu, Chien-Ning
Tain, You-Lin
author_sort Hsu, Chien-Ning
collection PubMed
description The cardiovascular system can be programmed by a diversity of early-life insults, leading to cardiovascular disease (CVD) in adulthood. This notion is now termed developmental origins of health and disease (DOHaD). Emerging evidence indicates hydrogen sulfide (H(2)S), a crucial regulator of cardiovascular homeostasis, plays a pathogenetic role in CVD of developmental origins. Conversely, early H(2)S-based interventions have proved beneficial in preventing adult-onset CVD in animal studies via reversing programming processes by so-called reprogramming. The focus of this review will first summarize the current knowledge on H(2)S implicated in cardiovascular programming. This will be followed by supporting evidence for the links between H(2)S signaling and underlying mechanisms of cardiovascular programming, such as oxidative stress, nitric oxide deficiency, dysregulated nutrient-sensing signals, activation of the renin–angiotensin system, and gut microbiota dysbiosis. It will also provide an overview from animal models regarding how H(2)S-based reprogramming interventions, such as precursors of H(2)S and H(2)S donors, may prevent CVD of developmental origins. A better understanding of cardiovascular programming and recent advances in H(2)S-based interventions might provide the answers to bring down the global burden of CVD.
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spelling pubmed-79146592021-03-01 Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target? Hsu, Chien-Ning Tain, You-Lin Antioxidants (Basel) Review The cardiovascular system can be programmed by a diversity of early-life insults, leading to cardiovascular disease (CVD) in adulthood. This notion is now termed developmental origins of health and disease (DOHaD). Emerging evidence indicates hydrogen sulfide (H(2)S), a crucial regulator of cardiovascular homeostasis, plays a pathogenetic role in CVD of developmental origins. Conversely, early H(2)S-based interventions have proved beneficial in preventing adult-onset CVD in animal studies via reversing programming processes by so-called reprogramming. The focus of this review will first summarize the current knowledge on H(2)S implicated in cardiovascular programming. This will be followed by supporting evidence for the links between H(2)S signaling and underlying mechanisms of cardiovascular programming, such as oxidative stress, nitric oxide deficiency, dysregulated nutrient-sensing signals, activation of the renin–angiotensin system, and gut microbiota dysbiosis. It will also provide an overview from animal models regarding how H(2)S-based reprogramming interventions, such as precursors of H(2)S and H(2)S donors, may prevent CVD of developmental origins. A better understanding of cardiovascular programming and recent advances in H(2)S-based interventions might provide the answers to bring down the global burden of CVD. MDPI 2021-02-05 /pmc/articles/PMC7914659/ /pubmed/33562763 http://dx.doi.org/10.3390/antiox10020247 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hsu, Chien-Ning
Tain, You-Lin
Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
title Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
title_full Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
title_fullStr Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
title_full_unstemmed Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
title_short Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?
title_sort preventing developmental origins of cardiovascular disease: hydrogen sulfide as a potential target?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914659/
https://www.ncbi.nlm.nih.gov/pubmed/33562763
http://dx.doi.org/10.3390/antiox10020247
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