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Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential

Heart failure (HF) is a leading cause of death in the United States, with a 5-year mortality rate of 50% despite modern pharmacological therapies. Plant-based diets are comprised of a diverse polyphenol profile, which lends to their association with reduced cardiovascular disease risk. Whether a pol...

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Autores principales: Najjar, Rami S., Feresin, Rafaela G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914665/
https://www.ncbi.nlm.nih.gov/pubmed/33562294
http://dx.doi.org/10.3390/ijms22041668
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author Najjar, Rami S.
Feresin, Rafaela G.
author_facet Najjar, Rami S.
Feresin, Rafaela G.
author_sort Najjar, Rami S.
collection PubMed
description Heart failure (HF) is a leading cause of death in the United States, with a 5-year mortality rate of 50% despite modern pharmacological therapies. Plant-based diets are comprised of a diverse polyphenol profile, which lends to their association with reduced cardiovascular disease risk. Whether a polyphenol-rich diet can slow the progression of or reverse HF in humans is not known. To date, in vitro and in vivo studies have reported on the protective role of polyphenols in HF. In this review, we will discuss the major mechanisms by which polyphenols mitigate HF in vitro and in vivo, including (1) reduced cardiac inflammation and oxidative stress, (2) reduced mitochondrial dysfunction, (3) improved Ca(2+) homeostasis, (4) increased survival signaling, and (5) increased sirtuin 1 activity.
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spelling pubmed-79146652021-03-01 Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential Najjar, Rami S. Feresin, Rafaela G. Int J Mol Sci Review Heart failure (HF) is a leading cause of death in the United States, with a 5-year mortality rate of 50% despite modern pharmacological therapies. Plant-based diets are comprised of a diverse polyphenol profile, which lends to their association with reduced cardiovascular disease risk. Whether a polyphenol-rich diet can slow the progression of or reverse HF in humans is not known. To date, in vitro and in vivo studies have reported on the protective role of polyphenols in HF. In this review, we will discuss the major mechanisms by which polyphenols mitigate HF in vitro and in vivo, including (1) reduced cardiac inflammation and oxidative stress, (2) reduced mitochondrial dysfunction, (3) improved Ca(2+) homeostasis, (4) increased survival signaling, and (5) increased sirtuin 1 activity. MDPI 2021-02-07 /pmc/articles/PMC7914665/ /pubmed/33562294 http://dx.doi.org/10.3390/ijms22041668 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Najjar, Rami S.
Feresin, Rafaela G.
Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential
title Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential
title_full Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential
title_fullStr Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential
title_full_unstemmed Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential
title_short Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential
title_sort protective role of polyphenols in heart failure: molecular targets and cellular mechanisms underlying their therapeutic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914665/
https://www.ncbi.nlm.nih.gov/pubmed/33562294
http://dx.doi.org/10.3390/ijms22041668
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