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New Antiadhesive Hydrophobic Polysiloxanes

Intrinsic hydrophobicity is the reason for efficient bacterial settlement and biofilm growth on silicone materials. Those unwelcomed phenomena may play an important role in pathogen transmission. We have proposed an approach towards the development of new anti-biofilm strategies that resulted in nov...

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Autores principales: Nowacka, Maria, Rygała, Anna, Kręgiel, Dorota, Kowalewska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914690/
https://www.ncbi.nlm.nih.gov/pubmed/33557279
http://dx.doi.org/10.3390/molecules26040814
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author Nowacka, Maria
Rygała, Anna
Kręgiel, Dorota
Kowalewska, Anna
author_facet Nowacka, Maria
Rygała, Anna
Kręgiel, Dorota
Kowalewska, Anna
author_sort Nowacka, Maria
collection PubMed
description Intrinsic hydrophobicity is the reason for efficient bacterial settlement and biofilm growth on silicone materials. Those unwelcomed phenomena may play an important role in pathogen transmission. We have proposed an approach towards the development of new anti-biofilm strategies that resulted in novel antimicrobial hydrophobic silicones. Those functionalized polysiloxanes grafted with side 2-(carboxymethylthioethyl)-, 2-(n-propylamidomethylthioethyl)- and 2-(mercaptoethylamidomethylthioethyl)- groups showed a wide range of antimicrobial properties towards selected strains of bacteria (reference strains Staphylococcus aureus, Escherichia coli and water-borne isolates Agrobacterium tumefaciens, Aeromonas hydrophila), fungi (Aureobasidium pullulans) and algae (Chlorella vulgaris), which makes them valuable antibacterial and antibiofilm agents. Tested microorganisms showed various levels of biofilm formation, but particularly effective antibiofilm activity was demonstrated for bacterial isolate A. hydrophila with high adhesion abilities. In the case of modified surfaces, the relative coefficient of adhesion for this strain was 18 times lower in comparison to the control glass sample.
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spelling pubmed-79146902021-03-01 New Antiadhesive Hydrophobic Polysiloxanes Nowacka, Maria Rygała, Anna Kręgiel, Dorota Kowalewska, Anna Molecules Article Intrinsic hydrophobicity is the reason for efficient bacterial settlement and biofilm growth on silicone materials. Those unwelcomed phenomena may play an important role in pathogen transmission. We have proposed an approach towards the development of new anti-biofilm strategies that resulted in novel antimicrobial hydrophobic silicones. Those functionalized polysiloxanes grafted with side 2-(carboxymethylthioethyl)-, 2-(n-propylamidomethylthioethyl)- and 2-(mercaptoethylamidomethylthioethyl)- groups showed a wide range of antimicrobial properties towards selected strains of bacteria (reference strains Staphylococcus aureus, Escherichia coli and water-borne isolates Agrobacterium tumefaciens, Aeromonas hydrophila), fungi (Aureobasidium pullulans) and algae (Chlorella vulgaris), which makes them valuable antibacterial and antibiofilm agents. Tested microorganisms showed various levels of biofilm formation, but particularly effective antibiofilm activity was demonstrated for bacterial isolate A. hydrophila with high adhesion abilities. In the case of modified surfaces, the relative coefficient of adhesion for this strain was 18 times lower in comparison to the control glass sample. MDPI 2021-02-04 /pmc/articles/PMC7914690/ /pubmed/33557279 http://dx.doi.org/10.3390/molecules26040814 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nowacka, Maria
Rygała, Anna
Kręgiel, Dorota
Kowalewska, Anna
New Antiadhesive Hydrophobic Polysiloxanes
title New Antiadhesive Hydrophobic Polysiloxanes
title_full New Antiadhesive Hydrophobic Polysiloxanes
title_fullStr New Antiadhesive Hydrophobic Polysiloxanes
title_full_unstemmed New Antiadhesive Hydrophobic Polysiloxanes
title_short New Antiadhesive Hydrophobic Polysiloxanes
title_sort new antiadhesive hydrophobic polysiloxanes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914690/
https://www.ncbi.nlm.nih.gov/pubmed/33557279
http://dx.doi.org/10.3390/molecules26040814
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