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Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease

Kingella kingae is a Gram-negative coccobacillus belonging to the Neisseriaceae family. In children less than 4 years old, K. kingae invasive infection can induce septic arthritis and osteomyelitis, and more rarely endocarditis, meningitis, ocular infections, and pneumonia. In adults, it may be a ca...

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Autores principales: Bonasoni, Maria Paola, Palicelli, Andrea, Dalla Dea, Giulia, Comitini, Giuseppina, Pazzola, Giulia, Russello, Giuseppe, Bertoldi, Graziella, Bardaro, Marcellino, Zuelli, Claudia, Carretto, Edoardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914692/
https://www.ncbi.nlm.nih.gov/pubmed/33557386
http://dx.doi.org/10.3390/diagnostics11020243
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author Bonasoni, Maria Paola
Palicelli, Andrea
Dalla Dea, Giulia
Comitini, Giuseppina
Pazzola, Giulia
Russello, Giuseppe
Bertoldi, Graziella
Bardaro, Marcellino
Zuelli, Claudia
Carretto, Edoardo
author_facet Bonasoni, Maria Paola
Palicelli, Andrea
Dalla Dea, Giulia
Comitini, Giuseppina
Pazzola, Giulia
Russello, Giuseppe
Bertoldi, Graziella
Bardaro, Marcellino
Zuelli, Claudia
Carretto, Edoardo
author_sort Bonasoni, Maria Paola
collection PubMed
description Kingella kingae is a Gram-negative coccobacillus belonging to the Neisseriaceae family. In children less than 4 years old, K. kingae invasive infection can induce septic arthritis and osteomyelitis, and more rarely endocarditis, meningitis, ocular infections, and pneumonia. In adults, it may be a cause of endocarditis. To date, K. kingae acute chorioamnionitis (AC) leading to preterm rupture of membranes (PPROM) and miscarriage has never been reported. Herein, we describe a case of intrauterine fetal death (IUFD) at 22 weeks’ gestation due to K. kingae infection occurred in a patient affected by undifferentiated connective tissue disease (UCTD) in lupus erythematosus systemic (LES) evolution with severe neutropenia. K. kingae was isolated in placental subamnionic swab and tissue cultures as well as fetal ear, nose, and pharyngeal swabs. Placental histological examination showed necrotizing AC and funisitis. In the fetus, neutrophils were observed within the alveoli and in the gastrointestinal lumen. Maternal medical treatment for UCTD was modified according to the K. kingae invasive infection. In the event of IUFD due to AC, microbiological cultures on placenta and fetal tissues should always be carried out in order to isolate the etiologic agent and target the correct medical treatment.
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spelling pubmed-79146922021-03-01 Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease Bonasoni, Maria Paola Palicelli, Andrea Dalla Dea, Giulia Comitini, Giuseppina Pazzola, Giulia Russello, Giuseppe Bertoldi, Graziella Bardaro, Marcellino Zuelli, Claudia Carretto, Edoardo Diagnostics (Basel) Case Report Kingella kingae is a Gram-negative coccobacillus belonging to the Neisseriaceae family. In children less than 4 years old, K. kingae invasive infection can induce septic arthritis and osteomyelitis, and more rarely endocarditis, meningitis, ocular infections, and pneumonia. In adults, it may be a cause of endocarditis. To date, K. kingae acute chorioamnionitis (AC) leading to preterm rupture of membranes (PPROM) and miscarriage has never been reported. Herein, we describe a case of intrauterine fetal death (IUFD) at 22 weeks’ gestation due to K. kingae infection occurred in a patient affected by undifferentiated connective tissue disease (UCTD) in lupus erythematosus systemic (LES) evolution with severe neutropenia. K. kingae was isolated in placental subamnionic swab and tissue cultures as well as fetal ear, nose, and pharyngeal swabs. Placental histological examination showed necrotizing AC and funisitis. In the fetus, neutrophils were observed within the alveoli and in the gastrointestinal lumen. Maternal medical treatment for UCTD was modified according to the K. kingae invasive infection. In the event of IUFD due to AC, microbiological cultures on placenta and fetal tissues should always be carried out in order to isolate the etiologic agent and target the correct medical treatment. MDPI 2021-02-04 /pmc/articles/PMC7914692/ /pubmed/33557386 http://dx.doi.org/10.3390/diagnostics11020243 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Bonasoni, Maria Paola
Palicelli, Andrea
Dalla Dea, Giulia
Comitini, Giuseppina
Pazzola, Giulia
Russello, Giuseppe
Bertoldi, Graziella
Bardaro, Marcellino
Zuelli, Claudia
Carretto, Edoardo
Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease
title Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease
title_full Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease
title_fullStr Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease
title_full_unstemmed Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease
title_short Kingella kingae Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease
title_sort kingella kingae intrauterine infection: an unusual cause of chorioamnionitis and miscarriage in a patient with undifferentiated connective tissue disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914692/
https://www.ncbi.nlm.nih.gov/pubmed/33557386
http://dx.doi.org/10.3390/diagnostics11020243
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