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TFEB Biology and Agonists at a Glance
Autophagy is a critical regulator of cellular survival, differentiation, development, and homeostasis, dysregulation of which is associated with diverse diseases including cancer and neurodegenerative diseases. Transcription factor EB (TFEB), a master transcriptional regulator of autophagy and lysos...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914707/ https://www.ncbi.nlm.nih.gov/pubmed/33562649 http://dx.doi.org/10.3390/cells10020333 |
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author | Chen, Mingyue Dai, Yashuang Liu, Siyu Fan, Yuxin Ding, Zongxian Li, Dan |
author_facet | Chen, Mingyue Dai, Yashuang Liu, Siyu Fan, Yuxin Ding, Zongxian Li, Dan |
author_sort | Chen, Mingyue |
collection | PubMed |
description | Autophagy is a critical regulator of cellular survival, differentiation, development, and homeostasis, dysregulation of which is associated with diverse diseases including cancer and neurodegenerative diseases. Transcription factor EB (TFEB), a master transcriptional regulator of autophagy and lysosome, can enhance autophagic and lysosomal biogenesis and function. TFEB has attracted a lot of attention owing to its ability to induce the intracellular clearance of pathogenic factors in a variety of disease models, suggesting that novel therapeutic strategies could be based on the modulation of TFEB activity. Therefore, TFEB agonists are a promising strategy to ameliorate diseases implicated with autophagy dysfunction. Recently, several TFEB agonists have been identified and preclinical or clinical trials are applied. In this review, we present an overview of the latest research on TFEB biology and TFEB agonists. |
format | Online Article Text |
id | pubmed-7914707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79147072021-03-01 TFEB Biology and Agonists at a Glance Chen, Mingyue Dai, Yashuang Liu, Siyu Fan, Yuxin Ding, Zongxian Li, Dan Cells Review Autophagy is a critical regulator of cellular survival, differentiation, development, and homeostasis, dysregulation of which is associated with diverse diseases including cancer and neurodegenerative diseases. Transcription factor EB (TFEB), a master transcriptional regulator of autophagy and lysosome, can enhance autophagic and lysosomal biogenesis and function. TFEB has attracted a lot of attention owing to its ability to induce the intracellular clearance of pathogenic factors in a variety of disease models, suggesting that novel therapeutic strategies could be based on the modulation of TFEB activity. Therefore, TFEB agonists are a promising strategy to ameliorate diseases implicated with autophagy dysfunction. Recently, several TFEB agonists have been identified and preclinical or clinical trials are applied. In this review, we present an overview of the latest research on TFEB biology and TFEB agonists. MDPI 2021-02-05 /pmc/articles/PMC7914707/ /pubmed/33562649 http://dx.doi.org/10.3390/cells10020333 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chen, Mingyue Dai, Yashuang Liu, Siyu Fan, Yuxin Ding, Zongxian Li, Dan TFEB Biology and Agonists at a Glance |
title | TFEB Biology and Agonists at a Glance |
title_full | TFEB Biology and Agonists at a Glance |
title_fullStr | TFEB Biology and Agonists at a Glance |
title_full_unstemmed | TFEB Biology and Agonists at a Glance |
title_short | TFEB Biology and Agonists at a Glance |
title_sort | tfeb biology and agonists at a glance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914707/ https://www.ncbi.nlm.nih.gov/pubmed/33562649 http://dx.doi.org/10.3390/cells10020333 |
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