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TFEB Biology and Agonists at a Glance

Autophagy is a critical regulator of cellular survival, differentiation, development, and homeostasis, dysregulation of which is associated with diverse diseases including cancer and neurodegenerative diseases. Transcription factor EB (TFEB), a master transcriptional regulator of autophagy and lysos...

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Autores principales: Chen, Mingyue, Dai, Yashuang, Liu, Siyu, Fan, Yuxin, Ding, Zongxian, Li, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914707/
https://www.ncbi.nlm.nih.gov/pubmed/33562649
http://dx.doi.org/10.3390/cells10020333
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author Chen, Mingyue
Dai, Yashuang
Liu, Siyu
Fan, Yuxin
Ding, Zongxian
Li, Dan
author_facet Chen, Mingyue
Dai, Yashuang
Liu, Siyu
Fan, Yuxin
Ding, Zongxian
Li, Dan
author_sort Chen, Mingyue
collection PubMed
description Autophagy is a critical regulator of cellular survival, differentiation, development, and homeostasis, dysregulation of which is associated with diverse diseases including cancer and neurodegenerative diseases. Transcription factor EB (TFEB), a master transcriptional regulator of autophagy and lysosome, can enhance autophagic and lysosomal biogenesis and function. TFEB has attracted a lot of attention owing to its ability to induce the intracellular clearance of pathogenic factors in a variety of disease models, suggesting that novel therapeutic strategies could be based on the modulation of TFEB activity. Therefore, TFEB agonists are a promising strategy to ameliorate diseases implicated with autophagy dysfunction. Recently, several TFEB agonists have been identified and preclinical or clinical trials are applied. In this review, we present an overview of the latest research on TFEB biology and TFEB agonists.
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spelling pubmed-79147072021-03-01 TFEB Biology and Agonists at a Glance Chen, Mingyue Dai, Yashuang Liu, Siyu Fan, Yuxin Ding, Zongxian Li, Dan Cells Review Autophagy is a critical regulator of cellular survival, differentiation, development, and homeostasis, dysregulation of which is associated with diverse diseases including cancer and neurodegenerative diseases. Transcription factor EB (TFEB), a master transcriptional regulator of autophagy and lysosome, can enhance autophagic and lysosomal biogenesis and function. TFEB has attracted a lot of attention owing to its ability to induce the intracellular clearance of pathogenic factors in a variety of disease models, suggesting that novel therapeutic strategies could be based on the modulation of TFEB activity. Therefore, TFEB agonists are a promising strategy to ameliorate diseases implicated with autophagy dysfunction. Recently, several TFEB agonists have been identified and preclinical or clinical trials are applied. In this review, we present an overview of the latest research on TFEB biology and TFEB agonists. MDPI 2021-02-05 /pmc/articles/PMC7914707/ /pubmed/33562649 http://dx.doi.org/10.3390/cells10020333 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Mingyue
Dai, Yashuang
Liu, Siyu
Fan, Yuxin
Ding, Zongxian
Li, Dan
TFEB Biology and Agonists at a Glance
title TFEB Biology and Agonists at a Glance
title_full TFEB Biology and Agonists at a Glance
title_fullStr TFEB Biology and Agonists at a Glance
title_full_unstemmed TFEB Biology and Agonists at a Glance
title_short TFEB Biology and Agonists at a Glance
title_sort tfeb biology and agonists at a glance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914707/
https://www.ncbi.nlm.nih.gov/pubmed/33562649
http://dx.doi.org/10.3390/cells10020333
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