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Serological Profile of Children and Young Adults with at Least One SARS-CoV-2 Positive Cohabitant: An Observational Study

At the end of 2019, a new disease caused by the novel coronavirus SARS-CoV-2 appeared in Wuhan Province in China. Children seemed to be infected less frequently than adults, and family clusters seemed to play an important role in the spread of the pandemic. The aim of this study is to evaluate the s...

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Autores principales: Farronato, Marco, Dolci, Carolina, Boccalari, Elisa, Izadi, Sara, Salvatierra Rios, Luis Hernan, Festa, Maurizio, Panetta, Valentina, De Vito, Danila, Tartaglia, Gianluca Martino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914765/
https://www.ncbi.nlm.nih.gov/pubmed/33557402
http://dx.doi.org/10.3390/ijerph18041488
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author Farronato, Marco
Dolci, Carolina
Boccalari, Elisa
Izadi, Sara
Salvatierra Rios, Luis Hernan
Festa, Maurizio
Panetta, Valentina
De Vito, Danila
Tartaglia, Gianluca Martino
author_facet Farronato, Marco
Dolci, Carolina
Boccalari, Elisa
Izadi, Sara
Salvatierra Rios, Luis Hernan
Festa, Maurizio
Panetta, Valentina
De Vito, Danila
Tartaglia, Gianluca Martino
author_sort Farronato, Marco
collection PubMed
description At the end of 2019, a new disease caused by the novel coronavirus SARS-CoV-2 appeared in Wuhan Province in China. Children seemed to be infected less frequently than adults, and family clusters seemed to play an important role in the spread of the pandemic. The aim of this study is to evaluate the serological profile of children and young adults between 4 and 16 years of age in order to assess the transmission patterns of COVID-19 between cohabitants. The subjects lived with at least one cohabitant who tested positive for the disease using a nasopharyngeal swab. To avoid contact with the disease, families were interviewed by telephone. Forty-nine children and adolescents with a mean age of 11 years were then subjected to a rapid lateral flow chromatographic test. Of them, seven (14.3%) were immunoglobulin G (IgG)-positive, and four (8.2%) were immunoglobulin M (IgM)-positive. In total, 16.3% of the tested sample had antibodies against SARS-CoV-2: this may confirm the lower vulnerability of children to COVID-19, despite the small sample size. The time from the negativization of the cohabitant until the test day may have influenced the results, especially when this timeframe is wide.
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spelling pubmed-79147652021-03-01 Serological Profile of Children and Young Adults with at Least One SARS-CoV-2 Positive Cohabitant: An Observational Study Farronato, Marco Dolci, Carolina Boccalari, Elisa Izadi, Sara Salvatierra Rios, Luis Hernan Festa, Maurizio Panetta, Valentina De Vito, Danila Tartaglia, Gianluca Martino Int J Environ Res Public Health Article At the end of 2019, a new disease caused by the novel coronavirus SARS-CoV-2 appeared in Wuhan Province in China. Children seemed to be infected less frequently than adults, and family clusters seemed to play an important role in the spread of the pandemic. The aim of this study is to evaluate the serological profile of children and young adults between 4 and 16 years of age in order to assess the transmission patterns of COVID-19 between cohabitants. The subjects lived with at least one cohabitant who tested positive for the disease using a nasopharyngeal swab. To avoid contact with the disease, families were interviewed by telephone. Forty-nine children and adolescents with a mean age of 11 years were then subjected to a rapid lateral flow chromatographic test. Of them, seven (14.3%) were immunoglobulin G (IgG)-positive, and four (8.2%) were immunoglobulin M (IgM)-positive. In total, 16.3% of the tested sample had antibodies against SARS-CoV-2: this may confirm the lower vulnerability of children to COVID-19, despite the small sample size. The time from the negativization of the cohabitant until the test day may have influenced the results, especially when this timeframe is wide. MDPI 2021-02-04 2021-02 /pmc/articles/PMC7914765/ /pubmed/33557402 http://dx.doi.org/10.3390/ijerph18041488 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Farronato, Marco
Dolci, Carolina
Boccalari, Elisa
Izadi, Sara
Salvatierra Rios, Luis Hernan
Festa, Maurizio
Panetta, Valentina
De Vito, Danila
Tartaglia, Gianluca Martino
Serological Profile of Children and Young Adults with at Least One SARS-CoV-2 Positive Cohabitant: An Observational Study
title Serological Profile of Children and Young Adults with at Least One SARS-CoV-2 Positive Cohabitant: An Observational Study
title_full Serological Profile of Children and Young Adults with at Least One SARS-CoV-2 Positive Cohabitant: An Observational Study
title_fullStr Serological Profile of Children and Young Adults with at Least One SARS-CoV-2 Positive Cohabitant: An Observational Study
title_full_unstemmed Serological Profile of Children and Young Adults with at Least One SARS-CoV-2 Positive Cohabitant: An Observational Study
title_short Serological Profile of Children and Young Adults with at Least One SARS-CoV-2 Positive Cohabitant: An Observational Study
title_sort serological profile of children and young adults with at least one sars-cov-2 positive cohabitant: an observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914765/
https://www.ncbi.nlm.nih.gov/pubmed/33557402
http://dx.doi.org/10.3390/ijerph18041488
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